Release pattern of dexamethasone after administration through an implant-mediated drug delivery device with an active plunger of super absorbent polymer

Original Article
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Abstract

The implant-mediated drug delivery system (IMDDS) is a novel, innovative device that allows drug delivery through bone marrow. The purpose of this study was to investigate the effect of an active plunger component made of super absorbent polymer (SAP) on the plasma concentration of dexamethasone released from the IMDDS. The IMDDSs were installed in a total of 18 rabbits. After complete healing, dexamethasone was loaded with the SAP active plunger and with water to cause expansion in the test group (n = 9), while only the drug was loaded in the control group, as per the original protocol (n = 9). The release patterns of each group were monitored for 2 weeks by measuring the plasma concentration of the drug. Both groups showed sustained release of drug. However, the test groups showed more rapid increase in plasma concentration and higher area under the curve (AUC) throughout the observation period. The incorporation of a SAP active plunger component in the IMDDS resulted in an increase in initial release of drug and higher bioavailability within the observation period of 2 weeks after dexamethasone administration.

Keywords

Osseogate Implant-mediated drug delivery system Super absorbent polymer Active plunger Dexamethasone 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Controlled Release Society 2018

Authors and Affiliations

  1. 1.Department of Oral Anatomy, School of DentistrySeoul National University and Dental Research InstituteSeoulSouth Korea

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