Microwaved bacterial cellulose-based hydrogel microparticles for the healing of partial thickness burn wounds
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Burn wound management is a complex process because the damage may extend as far as the dermis which has an acknowledged slow rate of regeneration. This study investigates the feasibility of using hydrogel microparticles composed of bacterial cellulose and polyacrylamide as a dressing material for coverage of partial-thickness burn wounds. The microparticulate carrier structure and surface morphology were investigated by Fourier transform infrared, X-ray diffraction, elemental analysis, and scanning electron microscopy. The cytotoxicity profile of the microparticles showed cytocompatibility with L929 cells. Dermal irritation test demonstrated that the hydrogel was non-irritant to the skin and had a significant effect on wound contraction compared to the untreated group. Moreover, histological examination of in vivo burn healing samples revealed that the hydrogel treatment enhanced epithelialization and accelerated fibroblast proliferation with wound repair and intact skin achieved by the end of the study. Both the in vitro and in vivo results proved the biocompatibility and efficacy of hydrogel microparticles as a wound dressing material.
KeywordsHydrogel microparticles Bacterial cellulose Cytotoxicity Partial-thickness burn wound Microwave irradiation
The authors would like to thank the Ministry of Higher Education, Malaysia (UKM-Farmasi-02-FRGS0192-2010) and the Universiti Kebangsaan Malaysia (INOVASI-2013-005) for their financial assistance and support.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
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