Drug Delivery and Translational Research

, Volume 6, Issue 1, pp 24–37 | Cite as

Scrolls: novel microparticulate systems for enhanced delivery to/across the skin

  • Irit Allon
  • Elka TouitouEmail author
Original Article


We describe the scroll system as a new microparticulate structured delivery system for enhanced delivery to/across the skin. The basic components of the scroll system are non-ionic surface active of the type of alkyl polyglycol ethers and a glycol. The unique structures are preserved with addition of various ingredients such as polymers, vegetable oils, pharmaceuticals, and permeation enhancers but are dismissed when amphiphile is withdrawn. The microparticles have a unique scroll structure with multiple “wrapping.” Besides enabling superior permeation of drugs into/across the skin, the drugs delivered by scroll systems were more effective in vitro and in vivo compared to controls. Model drugs presented high entrapment capacity in scroll systems. The systems are stable over time and are safe for skin application. In order to form, they require a small number of ingredients, simple preparation method, and are environment friendly. The scroll systems may be new potential tools in the dermal/transdermal pharmaceutical and cosmetic industry.


Scrolls Transdermal Topical Terbinafine hydrochloride Bacitracin Betamethasone diproprionate Ibuprofen Tramadol hydrochloride 



The authors wish to thank Mrs. Hiba Natsheh, Dr. Jana Zailer, and Mrs. Shatha Boukaileh from Prof. Elka Touitou’s lab for help and assistance in the animal experiments, Franz diffusion cells experiments and HPLC assays; Mr. Liron Issman from Prof. Yeshayahu Talmon’s lab in the Technion technology Institute Haifa, Dr. Eyal Shimoni from the Electron microscopy unit in Weizmann Institute Rehovot for their assistance with cryo-SEM imaging and Dr. Anna Radko from the Nanoscience and Nanotechnology Center for assistance with SPM and Raman spectroscopy.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Animal studies

All procedures performed in studies involving animals were in accordance with the ethical standards of the Hebrew University and Hadassah Medical Center.


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Copyright information

© Controlled Release Society 2015

Authors and Affiliations

  1. 1.Institute of Drug Research, School of Pharmacy, Faculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael

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