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Particle-based technologies for osteoarthritis detection and therapy

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Abstract

Osteoarthritis (OA) is a disease characterized by degradation of joints with the development of painful osteophytes in the surrounding tissues. Currently, there are a limited number of treatments for this disease, and many of these only provide temporary, palliative relief. In this review, we discuss particle-based drug delivery systems that can provide targeted and sustained delivery of imaging and therapeutic agents to OA-affected sites. We focus on technologies such as polymeric micelles and nano-/microparticles, liposomes, and dendrimers for their potential treatment and/or diagnosis of OA. Several promising studies are highlighted, motivating the continued development of delivery technologies to improve treatments for OA.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA

    Taylor E. Kavanaugh, Thomas A. Werfel & Craig L. Duvall

  2. University of Tennessee Health Science Center, Memphis, TN, USA

    Hongsik Cho & Karen A. Hasty

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  1. Taylor E. Kavanaugh
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  2. Thomas A. Werfel
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  5. Craig L. Duvall
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Correspondence to Craig L. Duvall.

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Kavanaugh, T.E., Werfel, T.A., Cho, H. et al. Particle-based technologies for osteoarthritis detection and therapy. Drug Deliv. and Transl. Res. 6, 132–147 (2016). https://doi.org/10.1007/s13346-015-0234-2

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  • DOI: https://doi.org/10.1007/s13346-015-0234-2

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