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Agitation extrême: concept d’excited delirium

Extreme agitation: concept of excited delirium syndrome

  • Cas Clinique Commenté / Commented Case Report
  • Published:
Annales françaises de médecine d'urgence

Résumé

Les services d’urgences préhospitaliers et hospitaliers sont confrontés de plus en plus fréquemment à des états d’agitation et à des épisodes de violence. Dans certains cas, cet état d’agitation présente un caractère extrême et incoercible, nécessitant une contention physique et chimique, et pouvant parfois conduire au décès du patient. Décrite sous le terme d’excited delirium syndrome (ExDS), cette entité n’est pas universellement reconnue et ne dispose pas à l’heure actuelle de définition standardisée. Bien que décrit au xix e siècle déjà, la fréquence de ce syndrome s’est amplifiée avec l’apparition de la consommation de cocaïne aux États-Unis dans la période 1980–2000. L’intervention policière, généralement nécessaire en phase préhospitalière, ainsi que les décès survenus lors de la maîtrise du patient ont contribué à la médiatisation de ce syndrome. Sa physiopathologie n’est pas connue, mais impliquerait une libération massive de catécholamines endogènes, en particulier dans la période qui suit un stress majeur, un effort physique intense (attitude « combative ») ou une contention physique (restriction ventilatoire), et pourrait alors être responsable d’une défaillance cardiaque aiguë potentiellement mortelle, par dysfonction myocardique ou arythmie. Les rares recommandations de prise en charge préconisent principalement d’identifier rapidement les patients, de les maîtriser au plus vite afin de les médicaliser et de pouvoir les sédater.

Urgence vitale, médiatisée et risquée pour les soignants, cette entité mérite d’être mieux comprise et définie. Nous rapportons le cas d’un patient répondant aux critères d’un ExDS et présentons un aperçu des définitions, traitements et physiopathologies exposés dans la littérature.

Abstract

Prehospital and hospital emergency departments faced more and more frequently states of agitation or violence episodes. In some cases, the agitation presents an extreme and uncontrollable character, requiring a physical and chemical restrain, which sometimes can lead to the death of the patient. Referred to Excited Delirium Syndrome (ExDS), this entity is not universally recognised and has at the present time no standardised definition. Although already described in the nineteenth century, the frequency of this syndrome has increased with the appearance of cocaine consumption in the United States during the 1980–2000 period. Police interventions, usually mandatory in the prehospital stage, along with the deaths occurred during the restrain of the patient, contributed to the mediatisation of this syndrome. Its physiopathology is unknown, but it could involve a massive liberation of endogenous catecholamines, particulary during the period following a major stress, an intense physical effort (combative behaviour) and a physical contention (with ventilatory restriction), and could then be responsible of an acute and potentially fatal heart failure, due to myocardial dysfunction or arrhythmia. The recommendations concerning care of these patients principally recommend a rapid identification of this condition and to control the patients as soon as possible, in order to medicalize and sedate them.

This life-threatening emergency, at high risk for the caregivers, is worth being better understood and defined. We report a case of a patient matching the criteria of an ExDS and presenting an insight on the definitions, treatments and pathophysiology issued from the literature.

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Références

  1. Grange JT, Corbett SW (2002) Violence against emergency medical services personnel. Prehosp Emerg Care 6:186–190

    Article  PubMed  Google Scholar 

  2. Petit JR (2005) Management of the acutely violent patient. Psychiatr Clin North Am 28:701–711

    Article  PubMed  Google Scholar 

  3. Ruttenber AJ, Lawler-Heavner J, Yin M, et al (1997) Fatal Excited Delirium following cocaïne use: epidemiologic findings provide new evidence for mechanisms of cocaïne toxicity. J Forensic Sci 42:25–31

    CAS  PubMed  Google Scholar 

  4. Whelan T (2008) The escalating trend of violence toward nurses. J Emerg Nurs 34:130–133

    Article  PubMed  Google Scholar 

  5. Hilliar K (2008) Police-recorded assaults on hospital premises in New South Wales: 1996–2006. Crime And Justice Bulletin, NSW Bureau of Crime Statistics and Research, 116:1–12

    Google Scholar 

  6. May DD, Grubbs LM (2002) The extent, nature, and precipitating factors of nurse assault among three groups of registered nurses in a regional medical center. J Emerg Nurs 28:11–17

    Article  PubMed  Google Scholar 

  7. Société francophone de médecine d’urgence (2003) Conférence de consensus. L’agitation en urgence (petit enfant excepté). JEUR 16:58–64

    Google Scholar 

  8. Vilke GM, Payne-James J, Karch SB (2012) Excited delirium syndrome (ExDS): redefining an old diagnosis. J Forensic Leg Med 19:7–11

    Article  PubMed  Google Scholar 

  9. Ross DL (1998) Factors associated with excited delirium deaths in police custody. Mod Pathol 11:1127

    CAS  PubMed  Google Scholar 

  10. Grant JR, Southall PE, Mealey J, et al (2009) Excited delirium deaths in custody: past and present. Am J Forensic Med Pathol 30:1

    Article  PubMed  Google Scholar 

  11. Robison D, Hunt S (2005) Sudden in-custody death syndrome. Advanced Emerg Nurs J 27:36

    Google Scholar 

  12. Storey ML (2011) Explaining the unexplainable: Excited Delirium Syndrome and its impact on the objective reasonableness standard for allegations of excessive force. St. Louis University Law J 56:633–663

    Google Scholar 

  13. Vilke GM, Debard ML, Chan TC, et al (2012) Excited Delirium Syndrome (ExDS): defining based on a review of the literature. J Emerg Med 43:897–905

    Article  PubMed  Google Scholar 

  14. ACEP Excited Delirium Task Force (2009) White paper report on excited delirium syndrome. American college of emergency physicians http://www.ccpicd.com/Documents/Excited%20Delirium%20Task%20Force.pdf (dernier accès le 21 octobre 2013)

    Google Scholar 

  15. Wetli CV, Fishbain DA (1985) Cocaine-induced psychosis and sudden death in recreational cocaine users. J Forensic Sci 30:873–880

    CAS  PubMed  Google Scholar 

  16. Mash DC, Duque L, Pablo J, et al (2009) Brain biomarkers for identifying excited delirium as a cause of sudden death. Forensic Sci Int 190:e13–e19

    Article  CAS  PubMed  Google Scholar 

  17. Niquille M, Gremion C, Welker S, Damsa C (2007) Prise en charge des états d’agitation extrahospitaliers: le point de vue de l’urgentiste. Rev Med Suisse 3:1839–1846

    CAS  PubMed  Google Scholar 

  18. Mock EF, Wrenn KD, Wright SW, et al (1998) Prospective field study of violence in emergency medical services calls. Ann Emerg Med 32:33–36

    Article  CAS  PubMed  Google Scholar 

  19. Richard P (2005) Deaths during police intervention. FBI Law Enforcement Bull 74:18–22

    Google Scholar 

  20. Stratton SJ, Rogers C, Brickett K, Grunzinski G (2001) Factors associated with sudden death of individuals requiring restraint for excited delirium. Am J Emerg Med 19:187–191

    Article  CAS  PubMed  Google Scholar 

  21. Sztajnkrycer MD, Baez AA (2005) Cocaine, excited delirium and sudden unexpected death. Emerg Med Serv 34:77–81

    PubMed  Google Scholar 

  22. National Institute of Justice Cooperative Agreement (2011) Special Panel Review of Excited Delirium. Weapons & Protective Systems Technologies Center, Pennsylvania State University, 1–44.

    Google Scholar 

  23. Pollanen MS, Chiasson DA, Cairns JT, Young JG (1998) Unexpected death related to restraint for excited delirium: a retrospective study of deaths in police custody and in the community. CMAJ 158:1603–1607

    CAS  PubMed Central  PubMed  Google Scholar 

  24. Takeuchi A, Ahern TL, Henderson SO (2011) Excited delirium. West J Emerg Med 12:77–83

    PubMed Central  PubMed  Google Scholar 

  25. Otahbachi M, Cevik C, Bagdure S, Nugent K (2010) Excited delirium, restraints, and unexpected death: a review of pathogenesis. Am J Forensic Med Pathol 31:107

    Article  PubMed  Google Scholar 

  26. Nassisi D, Yasuharu O (2007) ED Management of delirium and agitation. Emerg Med Pract 9:1–20

    Google Scholar 

  27. Cheney PR, Gossett L, Fullerton-Gleason L, et al (2006) Relationship of restraint use, patient injury, and assaults on EMS personnel. Prehosp Emerg Care 10:207–212

    Article  PubMed  Google Scholar 

  28. Lundin EJ (2009) Catecholamines in Simulated Arrest Scenarios. Ann Emerg Med 54:S98

    Article  Google Scholar 

  29. Morrison A, Sadler D (2001) Death of a psychiatric patient during physical restraint. Excited delirium — a case report. Med Sci Law 41:46–50

    CAS  Google Scholar 

  30. Moritz F, Jenvrin J, Canivet S, Gerault D (2004) Conduite à tenir devant une agitation aux urgences. Réanimation 13:500–506

    Google Scholar 

  31. Samuel E, Williams RB, Ferrell RB (2009) Excited delirium: Consideration of selected medical and psychiatric issues. Neuropsychiatr Dis Treat 5:61

    PubMed Central  PubMed  Google Scholar 

  32. TREC Collaborative Group (2003) Rapid tranquillisation for agitated patients in emergency psychiatric rooms: a randomised trial of midazolam versus haloperidol plus promethazine. BMJ 327: 708–713.

    Article  Google Scholar 

  33. Alexander J, Tharyan P, Adams C, et al (2004) Rapid tranquillisation of violent or agitated patients in a psychiatric emergency setting. Pragmatic randomised trial of intramuscular lorazepam v. haloperidol plus promethazine. Br J Psychiatry 185:63–69

    Article  PubMed  Google Scholar 

  34. Raveendran NS, Tharyan P, Alexander J, Adams CE (2007) Rapid tranquillisation in psychiatric emergency settings in India: pragmatic randomised controlled trial of intramuscular olanzapine versus intramuscular haloperidol plus promethazine. BMJ 335:865

    Article  CAS  PubMed  Google Scholar 

  35. Huf G, Coutinho ESF, Adams CE (2007) Rapid tranquillisation in psychiatric emergency settings in Brazil: pragmatic randomised controlled trial of intramuscular haloperidol versus intramuscular haloperidol plus promethazine. BMJ 335:869

    Article  CAS  PubMed  Google Scholar 

  36. Richards JR, Derlet RW, Duncan DR (1998) Chemical restraint for the agitated patient in the emergency department: lorazepam versus droperidol. J Emerg Med 16:567–573

    Article  CAS  PubMed  Google Scholar 

  37. Knott JC, Taylor DM, Castle DJ (2006) Randomized clinical trial comparing intravenous midazolam and droperidol for sedation of the acutely agitated patient in the emergency department. Ann Emerg Med 47:61–67

    Article  PubMed  Google Scholar 

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Correspondence to P. Gonin.

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Gonin, P., Yersin, B. & Carron, P.N. Agitation extrême: concept d’excited delirium . Ann. Fr. Med. Urgence 4, 33–38 (2014). https://doi.org/10.1007/s13341-013-0376-4

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  • DOI: https://doi.org/10.1007/s13341-013-0376-4

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