Abstract
Objective
We aimed to determine fatigue, depression, anxiety levels, and quality of life (QoL) in patients with prediabetes (PD) and to compare them with healthy subjects.
Materials and methods
A controlled, cross-sectional study was conducted. The patients, aged 18–65, were recruited from a tertiary care hospital. A total of 105 patients with newly diagnosed untreated PD and 48 normoglycemic subjects were included in the study. Participants did not know the diagnosis of PD and did not give psychological distress to the newly diagnosed. All participants were evaluated for body mass index (BMI), oral glucose tolerance test (OGTT), glycated hemoglobin (HbA1c), Fatigue Severity Scale (FSS), Hospital Anxiety and Depression Scale (HADS), Short Form-36 (SF-36).
Results
Age, gender, BMI were similar between groups. The scores of psychological measures were significantly worse in patients with PD compared with normoglycemic subjects (FSS median score: 4.33 vs. 2.22, HADS-anxiety mean score: 7.53 vs. 2.64, HADS-depression mean score: 6.33 vs. 2.79, SF-36 total median score: 52.81 vs. 79.89). The FSS, HADS and SF-36 scores showed a weak but statistically significant relationship with BMI. OGTT, HbA1c and HOMA-IR did not show any relationship with these scores.
Conclusion
Psychosocial problems may present in the prediabetic stage before the onset of diabetes.
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We express our deep appreciation to the study participants and the staff of the tertiary care hospital.
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The approval for this study was obtained from Erciyes University Local Ethics Committee (Approval Number: 2019/141, Date: 20.02.2019). This trial was performed in accordance with the Declaration of Helsinki and Good Clinical Practice. All study participants gave written consent prior to any trial-related activities, and the investigator retained the consent forms. All patients were informed about the study protocol and gave their written informed consents.
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Topaloğlu, U.S., Erol, K. Fatigue, anxiety and depression in patients with prediabetes: a controlled cross-sectional study. Diabetol Int 13, 631–636 (2022). https://doi.org/10.1007/s13340-022-00583-0
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DOI: https://doi.org/10.1007/s13340-022-00583-0