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Evaluation of some oxidative markers in diabetes and diabetic retinopathy

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Abstract

Aims

Diabetes mellitus and diabetic retinopathy (DR) are major public health concerns globally. Oxidative stress plays a central role in the pathogenesis of diabetes and DR. The aim of this study was to investigate the association of malondialdehyde, uric acid and bilirubin with diabetes and diabetic retinopathy development.

Methods

This study was conducted on 110 diabetics (with and without retinopathy). Beside 40 healthy individuals as a control group. The level of three markers (malondialdehyde, uric acid and bilirubin) was estimated in the studied groups. Receiver operating characteristic analysis and a logistic regression model was performed.

Results

The present study revealed significantly higher uric acid and malondialdehyde levels, while bilirubin showed significantly lower levels in diabetics compared to control and similarly in diabetic retinopathy compared to those without DR. Furthermore, combination of the three markers increased the accuracy and effect size for differentiation between diabetes with and without DR. In addition, higher levels of uric acid and malondialdehyde were associated with risk of diabetes and DR development.

Conclusion

This study concluded that higher levels of uric acid and malondialdehyde were associated with increase in the risk of diabetes and DR development, while bilirubin wasn’t associated with decreasing the risk of diabetes or DR. However, the combination of malondialdehyde, uric acid and bilirubin may be a valuable addition to the current options for the prognosis of DR. In addition, malondialdehyde may be independent predictor of diabetes and DR as well as uric acid may be used as independent biomarker to predict the risk of DR.

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Authors and Affiliations

  1. Biochemistry Division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt

    Hadeel Ahmed Shawki & Magdy M. Youssef

  2. Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

    Rasha Elzehery & Ekbal M. Abo-hashem

  3. Mansoura Ophthalmic Center, Mansoura University, Mansoura, Egypt

    Hadeel Ahmed Shawki & Maha Shahin

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  1. Hadeel Ahmed Shawki
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The Authors Hadeel Ahmed Shawki, Rasha Elzehery, Maha Shahin, Ekbal M.Abo-hashem, Magdy M. Youssef declared that they have no conflict of interest. The authors alone are responsible for the content and writing of this article.

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Shawki, H.A., Elzehery, R., Shahin, M. et al. Evaluation of some oxidative markers in diabetes and diabetic retinopathy. Diabetol Int 12, 108–117 (2021). https://doi.org/10.1007/s13340-020-00450-w

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