The relationship of one-leg standing time with peripheral nerve function and clinical neuropathy in patients with type 2 diabetes
This study aimed at exploring physical fitness including postural stability in relation to peripheral nerve function and clinical neuropathy in patients with type 2 diabetes across a wide range of ages.
We analyzed data collected from 139 patients with type 2 diabetes aged between 19 and 81 years, which included the peripheral nerve conduction parameters and coefficient of variation for normal R–R intervals (CVRR) at rest and during deep breathing. The results of neurological examinations to diagnose probable and confirmed diabetic neuropathies based on the minimal criteria proposed by the Toronto diabetic neuropathy expert group and a battery of physical fitness tests including one-leg standing time with eyes open were also assessed. Multiple linear and logistic regressions were used to estimate the relationships of the physical fitness measures with the parameters of peripheral and cardiac autonomic nerve functions and clinical neuropathies, respectively. Receiver operating characteristic curves were generated to depict the relation between sensitivity and specificity of one-leg standing time for probable and confirmed neuropathies.
After adjustment for age and other potential confounders, one-leg standing time correlated with peripheral and cardiac autonomic nerve functions as well as with probable and confirmed neuropathies. The one-leg standing time of 23 s was found to be 66 and 63% sensitive and 81 and 77% specific for diagnosing probable and confirmed neuropathies, respectively.
Short one-leg standing time was associated with peripheral and cardiac autonomic nerve dysfunction and clinical neuropathy in patients with type 2 diabetes, independent of age.
KeywordsPhysical fitness Postural stability Nerve conduction Heart rate variability Diabetic neuropathy
The authors gratefully acknowledge the contribution of Izumi Furukawa, Masanori Chiba and Yukinori Arakawa for data collection and analysis.
KS contributed to the study design, data collection, analysis, interpretation, writing and approving the manuscript. TH, AT and TY contributed to data collection and final approval of the manuscript. SS and TS contributed to reviewing the draft and final approval of the manuscript.
Compliance with ethical standards
Conflicts of interest
The authors have nothing to declare.
Human rights statement and informed consent
All analyses were conducted with the approval of the Ethical Committee of the Ohta Nishinouchi Hospital (approval no. N/A, approval date: 30 July 2014) and in accordance with the Helsinki Declaration of 1964 and later versions. No informed consent was given because existing data were retrieved and analyzed anonymously.
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