Is zinc an intra-islet regulator of glucagon secretion?
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More than a decade ago, zinc was suggested to have a role as an intra-islet regulator of glucagon secretion. Several lines of experimental evidence have since provided support for this hypothesis, though contradictory observations have also been reported. Meanwhile, Slc30A/ZnT8, a zinc transporter expressed in insulin and glucagon secretory granules, was identified. Furthermore, genome wide association analyses revealed it to be a candidate causative gene for type 2 diabetes mellitus. Recent progress in gene manipulation in animals yielded considerable information on the role of zinc in islet cells. In this mini-review, data pertaining the roles played by zinc in islet hormone secretion are summarized and discussed.
KeywordsGlucagon Insulin Zinc Slc30A8/ZnT8 α-cells
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Conflict of interest
Authors have nothing to declare related to this review.
This article dose not contain any studies with human or animal subjects performed by any of the authors.
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