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Evaluation of a new device for measurement of hemoglobin A1c for Japanese subjects

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An Erratum to this article was published on 05 November 2013

Abstract

Aim

The accuracy of HbA1c values measured by use of a new portable device (A1CNow+) was evaluated by comparison with values measured by high-performance liquid chromatography (HPLC).

Materials and methods

Venous blood samples were obtained from 144 subjects (111 diabetic and 33 non-diabetic subjects). HbA1c was measured by use of both the new device and HPLC for the same blood samples. The linearity of the results and the correlation between the two methods were evaluated.

Results

HbA1c measured by HPLC (HbA1c-HPLC) ranged between 4.4 and 12.3 % whereas values measured by the new device (HbA1c-new device) ranged between 4.5 and 12.7 %. There was a strong positive correlation between HbA1c-HPLC (Y) and HbA1c-new device (X) (Y = 0.951X + 0.197, r = 0.989; p < 0.001; 95 % confidence interval of the slope 0.928–0.975; 95 % confidence interval of the intercept 0.015–0.379).

Conclusion

HbA1c results obtained by use of the new device correlated strongly with those measured by HPLC, indicating the new device could be useful for clinical use.

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Abbreviations

NGSP:

National Glycohemoglobin Standardization Program

HPLC:

High-performance liquid chromatography

JDS:

Japan Diabetes Society

POCT:

Point-of-care test

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Acknowledgments

A1CNow+® units were kindly provided by Bayer HealthCare LLC (New York, USA).

Conflict of interest

The authors declare that A1CNow+® units were provided by Bayer HealthCare LLC (New York, USA).

Author information

Authors and Affiliations

  1. Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan

    Seiya Shimoda, Takako Maeda, Noboru Furukawa, Kenshi Ichinose, Kayo Taketa, Motoyuki Igata, Takafumi Senokuchi, Takeshi Matsumura & Eiichi Araki

Authors
  1. Seiya Shimoda
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  2. Takako Maeda
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  3. Noboru Furukawa
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  4. Kenshi Ichinose
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  5. Kayo Taketa
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  6. Motoyuki Igata
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  7. Takafumi Senokuchi
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  8. Takeshi Matsumura
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  9. Eiichi Araki
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Corresponding author

Correspondence to Eiichi Araki.

Additional information

S. Shimoda and T. Maeda contributed equally to this work.

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Shimoda, S., Maeda, T., Furukawa, N. et al. Evaluation of a new device for measurement of hemoglobin A1c for Japanese subjects. Diabetol Int 4, 112–116 (2013). https://doi.org/10.1007/s13340-012-0102-y

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  • DOI: https://doi.org/10.1007/s13340-012-0102-y

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