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A case of mitochondrial kidney disease with insulin resistance and hypoadiponectinemia

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Abstract

A 27-year-old woman with severe proteinuria, diabetes mellitus, sensorineural hearing impairment, and slight renal dysfunction was admitted to our hospital. The patient was diagnosed as having mitochondrial kidney disease, a rare disease with mitochondrial 3243 A to G mutation. The patient’s mother and younger sister had the same mitochondrial mutation, with the younger sister also having proteinuria. Differing from general mitochondrial diabetic patients with decreased insulin secretion, this patient showed insulin resistance. The thickening of the carotid intima-media, high brachial ankle pulse wave velocity, and ischemic change in cerebral white matter implied progressive arteriosclerosis. The patient also had hypoadiponectinemia even though she only had a small amount of visceral fat, and this hypoadiponectinemia may be one of the reasons behind the insulin resistance and arteriosclerosis. This case showed that insulin resistance cannot be the sole reason to exclude the possibility of mitochondrial kidney disease, and also showed the potential relationship between mitochondrial mutation and hypoadiponectinemia.

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Conflict of interest

The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Department of Endocrinology and Metabolism, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka, 530-0005, Japan

    Megu Yamaguchi Baden, Yuya Yamada, Yasumitsu Takahi, Yoshinari Obata, Kenji Saisho, Sachiko Tamba, Koji Yamamoto & Yuji Matsuzawa

  2. Department of Nephrology and Hypertension, Sumitomo Hospital, 5-3-20 Nakanoshima, Kita-ku, Osaka, 530-0005, Japan

    Jun Muratsu, Atsuyuki Morishima & Katsuhiko Sakaguchi

Authors
  1. Megu Yamaguchi Baden
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  2. Yuya Yamada
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  3. Yasumitsu Takahi
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  4. Yoshinari Obata
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  5. Kenji Saisho
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  6. Sachiko Tamba
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  7. Koji Yamamoto
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  8. Jun Muratsu
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  9. Atsuyuki Morishima
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  10. Katsuhiko Sakaguchi
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  11. Yuji Matsuzawa
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Corresponding author

Correspondence to Megu Yamaguchi Baden.

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Baden, M.Y., Yamada, Y., Takahi, Y. et al. A case of mitochondrial kidney disease with insulin resistance and hypoadiponectinemia. Diabetol Int 3, 54–60 (2012). https://doi.org/10.1007/s13340-011-0050-y

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  • DOI: https://doi.org/10.1007/s13340-011-0050-y

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