Abstract
Vaccination is the appropriate measure to protect military personnel against the hepatitis B virus (HBV) infection. Testing the military personnel for anti-HBs levels after vaccination is vital in re-vaccinating those that have not developed protective immunity. The aim of the current study was to determine the immunity in a group of vaccinated Sri Lankan military personnel (n = 150; age = 26–44 years) following a complete course of hepatitis B virus surface antigen (HBsAg) vaccination by assessing the antibodies against HBsAg (anti-HBs) levels. Three months after the last dose of the vaccination, blood samples were collected from the study population and tested for anti-HBs levels using a commercially available ELISA. Of the 150 military service men tested, 139 (92.67%) had anti-HBs levels higher than 10 mIU/mL, WHO approved levels for protective immunity against HBV infection. Of the 139 that had sufficient anti-HBs levels, 24% (36/150) had anti-HBs levels between 10 and 100 mIU/mL and 68.67% (103/150) had anti-HBs levels > 100 mIU/mL. Overall, 7.33% (11/150) participants had anti-HBs levels < 10 mIU/mL. Sero-conversion to > 10 mIU/mL anti-HBs was more than 90% in those that were less than 40 years of age and it was less than 90% in those that were more than 40 years of age.
References
Abedi F, Madani H, Asadi A, Nejatizadeh A. Significance of blood related high risk behaviors and horizontal transmission of hepatitis B virus in Iran. Arch Virol. 2011;15:629–35.
Ahad A, Alim A, Guho A, Islam QT, Azad KBK. Role of booster dose on antibody titer after recombinant hepatitis B vaccine. J Med. 2009;10:67–76.
Baddevithana AK, Noordeen F, Mendis CM, Abeykoon AMSB. Immune response to hepatitis B vaccine in a group of vaccinees in the Faculty of Allied Health Sciences of the University of Peradeniya. Sri Lankan J Infect Dis. 2015;5:7–12.
Chathuranga LS, Noordeen F, Abeykoon AMSB. Immune response to hepatitis B vaccine in a group of health care workers in Sri Lanka. Int J Infect Dis. 2013. https://doi.org/10.1016/j.ijid.2013.04.009.
Esteghamati A, Keshtkar AA, Nadjafi L, Gouya MM, Salaramoli M, Roshandel G, et al. Hepatitis B vaccination coverage among Iranian children aged 15–26 months in 2006. East Mediterr Health J. 2011;17:93–100.
Fathimoghaddam F, Hedayati MMR, Bidkhori HR, Bidkhori HR, Ahmadi S, Sima HR. Prevalence of hepatitis B antigen positivity in the general population of Mashhad, Iran. Hepat Mon. 2011;11:346–50.
Goldstein ST, Zhou F, Hadler SC, Bell BP, Mast EE, Margolis HS. A mathematical model to estimate global hepatitis B disease burden and vaccination impact. Int J Epidemiol. 2005;34:1329–39.
Keeffe EB. Acute hepatitis A and B in patients with chronic liver disease: prevention through vaccination. Am J Med. 2005;118:215–75.
Kunal Das RK, Gupta Kumar V, Kar P. Immunogenicity and reactogenicity of a recombinant hepatitis B vaccine in subjects over 40 years of age and response to a booster among non-responders. World J Gastroenterol. 2003;9:1132–4.
Livramento AD, Cordova CM, Scaraveli NG, Tonial GC, Spada C, Treitinger A. Anti-HBs levels among children and adolescents with complete immunization schedule against hepatitis B virus. A cross sectional study in Blumenau, State of Santa Catarina, Brazil, 2007–2008. Rev Soc Bras Med Trop. 2011;44:412–5.
McMahon BJ, Bruden DL, Petersen KM, Hedberg CW, Hanson M, Osterholm MT. Antibody level and protection after hepatitis B vaccination. Result of a 15 years follow up. Ann Intern Med. 2005;142:333–41.
Noordeen F. Hepatitis B virus infection: an insight into infection outcomes and recent treatment options. Virus Dis. 2015;26:1–8.
Noordeen F, Pitchai FNN, Rafeek RA. A review of hepatitis B virus infection in Sri Lanka. Sri Lankan J Infect Dis. 2015;5:42–50.
Perera J, Perera B, Gamage S. Seroconversion after hepatitis B vaccination in healthy young adults and the effect of a booster dose. Ceylon Med J. 2002;47:6–8.
Piratheepkumar V, Kulendran S, Nadarajah S, Murugananthan K. Hepatitis B vaccine immunogenicity among nurses of a hospital. Ceylon Med J. 2014;59:59–60.
Rendi WP, Kundi M, Stemberger H, Wiedermann G, Holzmann H, Hofer M, et al. Antibody response to three recombinant hepatitis B vaccines: comparative evaluation of multicenter travel clinic based experience. Vaccine. 2001;19:2055–60.
Wood RC, MacDonald KL, White KE, et al. Risk factors for lack of detectable antibody following hepatitis B vaccination of Minnesota health care workers. JAMA. 1993;270:2935–72.
Yu AS, Cheung RC, Keeff EB. Hepatitis B vaccines. Infect Dis Clin N Am. 2006;20:27–45.
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This study was supported by Postgraduate Institute of Science, University of Peradeniya, Sri Lanka.
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Noordeen, F., Karunaratne, H.M.S., Nawaratne, V. et al. Protective immunity against hepatitis B virus infection in a group of vaccinated Sri Lankan military service men following a complete course of vaccination. VirusDis. 30, 462–464 (2019). https://doi.org/10.1007/s13337-019-00546-1
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DOI: https://doi.org/10.1007/s13337-019-00546-1