, Volume 30, Issue 1, pp 3–12 | Cite as

ssDNA viruses: key players in global virome

  • V. G. MalathiEmail author
  • P. Renuka Devi
Review Article


Single-stranded (ss)DNA viruses are extremely widespread, infect diverse hosts from all three domains of life and include important pathogens. Most ssDNA viruses possess small genomes that replicate by the rolling-circle-like mechanism initiated by a distinct virus-encoded endonuclease. High throughput genome sequencing and improved bioinformatics tools have yielded vast information on presence of ssDNA viruses in diverse habitats. The simple genome of ssDNA viruses have high propensity to undergo mutation and recombination often emerging as threat to human civilization. Interestingly their genome is found embedded in fossils dating back to million years. The unusual evolutionary history of ssDNA viruses reveal evidences of horizontal gene transfer, sometimes between different species and genera.


ssDNA CRESS viruses Rolling circle replication 



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Copyright information

© Indian Virological Society 2019

Authors and Affiliations

  1. 1.Department of Plant PathologyTamil Nadu Agricultural UniversityCoimbatoreIndia
  2. 2.Department of SericultureForest College and Research InstituteMettupalayamIndia

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