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Camelpox, an emerging orthopox viral disease

Abstract

Camelpox is considered as emerging public health problem during this decade due to increased reported cases and outbreaks in camels. Camelpox is a contagious, often sporadic, and notifiable skin disease of camelids and is socio-economically significant as it incurs considerable loss in terms of morbidity, mortality, loss of weight and reduction in milk yield and confined to camel-rearing countries. The causative agent, camelpox virus (CMLV) is genetically closely related to variola virus and has gained much attention from researchers due to its recent emergence in human. The virus carrying genes responsible for host immune evasion mechanisms owing to the threat posed by potential bio-warfare agents. Although the disease can be diagnosed based on clinical features, the similar confounding skin lesions necessitate identification, detection and differentiation of the CMLV by molecular techniques. Vaccines are available in some countries and the available live attenuated vaccine provides long-lasting immunity. Further, novel highly sensitive and specific techniques would be useful in the identification of emerging and re-emerging virus, thereby therapeutic, prophylactic, preventive measures would be applied in time to curtail further spread of camelpox like other zoonotic diseases. This review provide overview of the camelpox particularly on its epidemiology, pathogenesis and biology of the disease, diagnostic approaches and control measures.

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References

  1. 1.

    Afonso CL, Tulman ER, Lu Z, Zsak L, Sandybaev NT, Kerembekova UZ, Zaitsev VL, Kutish GF, Rock DL. The genome of camelpox virus. Virology. 2002;295(1):1–9.

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    Al Hendi AB, Abuelzein EM, Gameel AA, Hassanein MM. A slow-spreading mild form of camelpox infection. J Vet Med B. 1994;41:71–3.

    Article  CAS  Google Scholar 

  3. 3.

    Alcami A, Smith GL. Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity. J Virol. 1995;69:4633–9.

    PubMed  CAS  Google Scholar 

  4. 4.

    Alcami A, Symons JA, Khanna A, Smith GL. Poxviruses: capturing cytokines and chemokines. Semin Virol. 1998;8:419–27.

    Article  CAS  Google Scholar 

  5. 5.

    Al-Ziabi O, Nishikawa H, Meyer H. The first outbreak of camelpox in Syria. J Vet Med Sci. 2007;69(5):541–3.

    Article  CAS  Google Scholar 

  6. 6.

    Andrei G, Gammon DB, Fiten P, De Clercq E, Opdenakker G, Snoeck R, Evans DH. Cidofovir resistance in vaccinia virus is linked to diminished virulence in mice. J Virol. 2006;80:9391–401.

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    Azwai SM, Carter SD, Woldehiwet Z, Wernery U. Serology of Orthopoxvirus cameli infection in dromedary camels: analysis by ELISA and western blotting. Comp Immunol Microbiol Infect Dis. 1996;19(1):65–78.

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Balamurugan V, Bhanuprakash V, Hosamani M, Kallesh DJ, Bina Chauhan, Venkatesan G, Singh RK. A polymerase chain reaction strategy for the diagnosis of camelpox. J Vet Diag Invest. 2009;21(2):231–7.

    Article  Google Scholar 

  9. 9.

    Bary M, Babiuk S. Camelpox: target for eradication? Antiviral Res. 2011;92:164–6.

    Article  Google Scholar 

  10. 10.

    Baxby D, Ramyar H, Hessami M, Ghaboosi B. A comparison of the response of camels to intradermal inoculation with camelpox and smallpox viruses. Infect Immun. 1975;11:617–21.

    PubMed  CAS  Google Scholar 

  11. 11.

    Baxby D. Smallpox viruses from camels in Iran. Lancet. 1972;7786:1063–5.

    Article  Google Scholar 

  12. 12.

    Baxby D. Differentiation of smallpox and camelpox viruses in cultures of human and monkey cells. J Hyg (London). 1974;72:251–4.

    Article  CAS  Google Scholar 

  13. 13.

    Bera BC, Shanmugasundaram K, Barua S, Venkatesan G, Virmani N, Riyesh T, Gulati BR, Bhanuprakash V, Vaid RK, Kakker NK, Malik P, Bansal M, Gadvi S, Singh RV, Yadav V, Sardarilal, Nagarajan G, Balamurugan V, Hosamani M, Pathak KM, Singh RK. Zoonotic cases of camelpox infection in India. Vet Microbiol. 2011;152(1–2):29–38.

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Bett B, Jost C, Allport R, Mariner J. Using participatory epidemiological techniques to estimate the relative incidence and impact on livelihoods of livestock diseases amongst nomadic pastoralists in Turkana South District, Kenya. Prev Vet Med. 2009;90:194–203.

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    Bhanuprakash V, Prabhu M, Venkatesan G, Balamurugan V, Hosamani M, Pathak KML, Singh RK. Camelpox: epidemiology, diagnosis and control measures. Expert Rev Anti Infect Ther. 2010;8(10):1187–201.

    PubMed  Article  Google Scholar 

  16. 16.

    Bhanuprakash V, Balamurugan V, Hosamani M, Venkatesan G, Chauhan B, Srinivasan VA, Chauhan RS, Pathak KM, Singh RK. Isolation and characterization of Indian isolates of Camelpox viruses. Trop Anim Health Prod. 2010;42(6):1271–5.

    PubMed  Article  CAS  Google Scholar 

  17. 17.

    Borisovich Yu F. Camelpox. (Little-known contagious diseases of animals) etd by F. M. Orlov. Izdatel’stvo Kolos, USSR, 2nd edn., 32–42 (Ru). Vet Bull. 1973;44(9):139.

    Google Scholar 

  18. 18.

    Boulter EA, Zwartouw HT, Titmuss DH, Maber HB. The nature of the immune state produced by inactivated vaccinia virus in rabbits. Am J Epidemol. 1971;94(6):612–20.

    CAS  Google Scholar 

  19. 19.

    Bowie A, Kiss-Toth E, Symons JA, Smith GL, Dower SK, O’Neill LA. A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc Natl Acad Sci USA. 2000;97(18):10162–7.

    PubMed  Article  CAS  Google Scholar 

  20. 20.

    Chauhan RS, Kaushik RK. Isolation of camelpox virus in India. Brit Vet J. 1987;143:581–2.

    Article  CAS  Google Scholar 

  21. 21.

    Coetzer JAW. Poxviridae. In: Coetzer JAW, Tustin RC, editors. Infectious diseases of livestock, vol. 2. 2nd ed. Southern Africa: Oxford University Press; 2004. p. 1265–7.

    Google Scholar 

  22. 22.

    Cyrklaff M, Risco C, Fernández JJ, Jiménez MV, Estéban M, Baumeister W, Carrascosa JL. Cryo-electron tomography of vaccinia virus. Proc Natl Acad Sci USA. 2005;102(8):2772–7.

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    Damaso CR, Esposito JJ, Condit RC, Moussatche N. An emergent poxvirus from humans and cattle in Rio de Janeiro state: cantagalo virus may derive from Brazilian small pox vaccine. Virology. 2000;277:439–49.

    PubMed  Article  CAS  Google Scholar 

  24. 24.

    Damon I. Poxviruses. In: Knipe DM, Howley PM, editors. Fields virology. 5th edition ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 2947–75.

    Google Scholar 

  25. 25.

    Davies FG, Mungai JN, Shaw T. Characteristics of a Kenyan camelpox virus. J Hyg. 1975;7:381–5.

    Article  Google Scholar 

  26. 26.

    De Clercq E, Sakuma T, Baba M, Pauwels R, Balzarini J, Rosenberg I, Holy A. Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidine. Antiviral Res. 1987;8:261–72.

    PubMed  Article  Google Scholar 

  27. 27.

    Duraffour S, Andrei G, Snoeck R. Tecovirimat, a p37 envelope protein inhibitor for the treatment of smallpox infection. IDrugs. 2010;13:181–91.

    PubMed  CAS  Google Scholar 

  28. 28.

    Duraffour S, Matthys P, van Den Oord JJ, De Schutter T, Mitera T, Snoeck R, Andrei G. Study of camelpox virus pathogenesis in athymic nude mice. PLoS One. 2011;6:e21561.

    PubMed  Article  CAS  Google Scholar 

  29. 29.

    Duraffour S, Snoeck R, de Vos R, van Den Oord JJ, Crance JM, Garin D, Hruby DE, Jordan R, De Clercq E, Andrei G. Activity of the anti orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft cultures. Antivir Ther. 2007;12:1205–16.

    PubMed  CAS  Google Scholar 

  30. 30.

    Duraffour S, Snoeck R, Fiten P, Opdenakker G, Andrei G. Selection and characterization of (S)-1-[3-hydroxy-2-(phosphonomethoxypropyl)-2,6-diaminopurine [HPMPDAP] resistant Camelpox viruses. Antivir Res. 2009;82:A67–8.

    Article  Google Scholar 

  31. 31.

    Duraffour S, Snoeck R, Krecmerova M, Van den OJ, de Vos R, Holy A, Crance JM, Garin D, De Clercq E, Andrei G. Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrob Agents Chemother. 2007;51:4410–9.

    PubMed  Article  CAS  Google Scholar 

  32. 32.

    Duraffour S, Vigne S, Garcel A, Jordan R, Hruby DE, Crance JM, Garin D, Andrei G, Snoeck R. Antiviral potency of ST-246 on the production of enveloped orthopoxviruses and characterization of ST-246 resistant vaccinia, cowpox and camelpox viruses. Antivir Res. 2008;78:A29–30.

    Article  Google Scholar 

  33. 33.

    Duraffour S, Meyer H, Andrei G, Snoeck R. Camelpox virus. Antivir Res. 2011;92(2):167–86.

    PubMed  Article  CAS  Google Scholar 

  34. 34.

    El Harrak M, Loutfi C. La variole du dromadaire chez le jeune au Maroc. Isolement et identification du virus. Mise au point du vaccin et application à la prophylaxie. Revue d’élevage et de médecine vétérinaire des pays tropicaux. 2000;53:165–7.

    Google Scholar 

  35. 35.

    Elliot H, Tuppurainen E. Camelpox. Manual of diagnostic tests and vaccines for terrestrial animals, Vol. 2, Chap. 2.9.2. 2008. p. 177–84.

  36. 36.

    Eskra L, Mathison A, Splitter G. Microarray analysis of mRNA levels from RAW264.7 macrophages infected with Brucella abortus. Infect Immun. 2003;71:1125–33.

    PubMed  Article  CAS  Google Scholar 

  37. 37.

    Fenner F, Wittek R, Dumbell KR. The orthopox viruses. New York: Academic Press Inc.; 1989.

    Google Scholar 

  38. 38.

    Geserick P, Kaiser F, Klemm U, Kaufmann SH, Zerrahn J. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Intl Immunol. 2004;16:1535–48.

    Article  CAS  Google Scholar 

  39. 39.

    Gitao CG. An investigation of camelpox outbreaks in two principal camel (Camelus dromedarius) rearing areas of Kenya. Revue scientifique et technique/Office international des épizooties. 1997;16:841–7.

    CAS  Google Scholar 

  40. 40.

    Gubser C, Bergamaschi D, Hollinshead M, Lu X, van Kuppeveld FJ, Smith GL. A new inhibitor of apoptosis from vaccinia virus and eukaryotes. PLoS Pathog. 2007;3:e17.

    PubMed  Article  Google Scholar 

  41. 41.

    Gubser C, Goodbody R, Ecker A, Brady G, O’Neill LA, Jacobs N, Smith GL. Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus virulence. J GenVirol. 2007;88:1667–76.

    CAS  Google Scholar 

  42. 42.

    Gubser C, Smith GL. The sequence of camelpox virus shows it is most closely related to variola virus, the cause of smallpox. J GenVirol. 2002;83(4):855–72.

    CAS  Google Scholar 

  43. 43.

    Hafez SM, Al-Sukayran A, Dela Cruz D, Mazloum KS, Al-Bokmy AM, Al-Mukayyel A, Amjad AM. Development of a live cell culture camelpox vaccine. Vaccine. 1992;8(10):533–9.

    Article  Google Scholar 

  44. 44.

    Huemer HP, Hönlinger B, Höpfl R. A simple restriction fragment PCR approach for discrimination of human pathogenic old world animal orthopoxvirus species. Can J Microbiol. 2008;54(2):159–62.

    PubMed  Article  CAS  Google Scholar 

  45. 45.

    Jezek Z, Kriz B, Rothbauer V. Camelpox and its risk to the human population. J Hyg Epidemiol Microbiol Immunol. 1983;27:29–42.

    PubMed  CAS  Google Scholar 

  46. 46.

    Kern ER, Hartline C, Harden E, Keith K, Rodriguez N, Beadle JR, Hostetler KY. Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir. Antimicrob Agents Chemother. 2002;46:991–5.

    PubMed  Article  CAS  Google Scholar 

  47. 47.

    Khalafalla AI, Ali YH. Observations on risk factors associated with some camel viral diseases of camels in Sudan. In: Proceedings of the 12th international conference of the Association of Institutions of Tropical Veterinary Medicine. Montpellier, France, 20–22 August 2007; pp. 101–105.

  48. 48.

    Khalafalla AI, Buttner M, Rziha HJ. Polymerase chain reaction (PCR) for rapid diagnosis and differentiation of Para and orthopox virus infections in camels. FAO/IAEA International Animal Production and Health in Developing Countries, Vienna, Austria. 6–10 Oct, 2003.

  49. 49.

    Khalafalla AI, El Dirdiri GA. Laboratory and field investigations of a live attenuated and an inactivated camelpox vaccine. J Cam Prac Res. 2003;10(2):191–200.

    Google Scholar 

  50. 50.

    Khalafalla AI, Mohamed MEM, Agab H. Serological survey in camels of the Sudan for prevalence of antibodies to camelpox virus using ELISA technique. J Cam Prac Res. 1998;5:197–200.

    Google Scholar 

  51. 51.

    Kinne J, Cooper JE, Wernery U. Pathological studies on camelpox lesions of the respiratory system in the United Arab Emirates (UAE). J Comp Pathol. 1998;118:257–66.

    PubMed  Article  CAS  Google Scholar 

  52. 52.

    Kriz B. A study of camelpox in Somalia. J Comp Pathol. 1982;92:1–8.

    PubMed  Article  CAS  Google Scholar 

  53. 53.

    Leese S. Two diseases of young camels. J Trop Vet Sci. 1909;4:1.

    Google Scholar 

  54. 54.

    Marennikova SS. The results of examinations of wildlife monkeys for the presence of antibodies and viruses of the pox group. Voprosy Virusolgii. 1975;3:321–6.

    Google Scholar 

  55. 55.

    Marodam V, Nagendrakumar SB, Tanwar VK, Thiagarajan D, Reddy GS, Tanwar RK, Srinivasan VA. Isolation and identification of camelpox virus. Ind J Anim Sci. 2006;76:326–7.

    Google Scholar 

  56. 56.

    Meyer H, Pfeffer M, Rziha HJ. Sequence alterations within and downstream of the A-type inclusion protein genes allow differentiation of Orthopoxvirus species by polymerase chain reaction. J Gen Virol. 1994;75:1975–81.

    PubMed  Article  CAS  Google Scholar 

  57. 57.

    Meyer H, Ropp SL, Esposito JJ. Gene for A-type inclusion body protein is useful for a polymerase chain reaction assay to differentiate orthopoxviruses. J Virol Methods. 1997;64:217–21.

    PubMed  Article  CAS  Google Scholar 

  58. 58.

    Moss B, Shisler JL. Immunology 101 at poxvirus U: immune evasion genes. Semin Immunol. 2001;13(1):59–66.

    PubMed  Article  CAS  Google Scholar 

  59. 59.

    Moss B. Poxviridae: the viruses and their replication. In: Knipe DM, Howley PM, editors. Fields virology. 5th ed. Philadelphia: Lippincot Williams & Wilkins; 2007. p. 2905–45.

    Google Scholar 

  60. 60.

    Najarro P, Traktman P, Lewis JA. Vaccinia virus blocks gamma interferon signal transduction: viral VH1 phosphatase reverses Stat1 activation. J Virol. 2001;75(7):3185–96.

    PubMed  Article  CAS  Google Scholar 

  61. 61.

    Nazarian SH, McFadden G. Immunomodulation by poxviruses. In: Schmidt AA, Weber A, Mercer O, editors. Poxviruses. Basel: Birkhäuser Verlag; 2007. p. 273–96.

    Chapter  Google Scholar 

  62. 62.

    Nguyen BV, Guerre L, Saint-Martin G. Preliminary study of the safety and immunogenicity of the attenuated VD47/25 strain of camelpox virus. Rev Elev Med Vet Pays Trop. 1996;49:189–94.

    Google Scholar 

  63. 63.

    Nitsche A, Ellerbrok H, Pauli G. Detection of orthopoxvirus DNA by real- time PCR and variola virus DNA by melting analysis. J Clin Microbiol. 2004;42(3):1207–13.

    PubMed  Article  CAS  Google Scholar 

  64. 64.

    Nothelfer HB, Wernery U, Czerny CP. Camelpox: antigen detection within skin lesions-immunohistochemistry as a simple method of etiological diagnosis. J Cam Prac Res. 1995;2(2):119–21.

    Google Scholar 

  65. 65.

    Panning M, Asper M, Kramme S, Schmitz H, Drosten C. Rapid detection and differentiation of human pathogenic orthopox viruses by a fluorescence resonance energy transfer real- time PCR assay. Clin Chem. 2004;50:702–8.

    PubMed  Article  CAS  Google Scholar 

  66. 66.

    Perdiguero B, Esteban M. The interferon system and vaccinia virus evasion mechanisms. J Interferon Cytokine Res. 2009;29:581–98.

    PubMed  Article  CAS  Google Scholar 

  67. 67.

    Pfeffer M, Meyer H, Wernery U, Kaaden OR. Comparison of camelpox viruses isolated in Dubai. Vet Microbiolol. 1996;49:135–46.

    Article  CAS  Google Scholar 

  68. 68.

    Pfeffer M, Neubauer H, Wernery U, Kaaden OR, Meyer H. Fatal form of camelpox virus infection. Vet J. 1998;155:107–9.

    PubMed  Article  CAS  Google Scholar 

  69. 69.

    Pfeffer M, Wernery U, Kaaden OR, Meyer H. Diagnostic procedures for poxvirus infections in camelids. J Cam Prac Res. 1998;5:189–95.

    Google Scholar 

  70. 70.

    Ramyar H, Hessami M. Isolation, cultivation and characterisation of camelpox virus. Zentralbl Veterinarmed B. 1972;19:182–9.

    PubMed  Article  CAS  Google Scholar 

  71. 71.

    Renner-Muller IC, Meyer H, Munz E. Characterization of camelpoxvirus isolates from Africa and Asia. Vet Microbiol. 1995;45:371–81.

    PubMed  Article  CAS  Google Scholar 

  72. 72.

    Rheinbaden FV, Gebel J, Exner, et al. Environmental resistance, disinfection, and sterilization of poxviruses. In: Schmidt AA, Weber A, Mercer O, editors. Poxviruses. Basel: Birkhäuser Verlag; 2007. p. 397–405.

    Chapter  Google Scholar 

  73. 73.

    Ropp SL, Jin Q, Knight JC, Massung RF. Esposito. Polymerase chain reaction strategy for identification and differentiation of smallpox and other orthopoxviruses. J Clin Microbiol. 1995;33:2069–76.

    PubMed  CAS  Google Scholar 

  74. 74.

    Roslyakov AA. Comparative ultrastructure of viruses of camelpox, a pox-like disease of camels (‘‘auzdik’’) and contagious ecthyma of sheep. Vopr Virusol. 1972;17:26–30.

    Google Scholar 

  75. 75.

    Sadykov RG. Cultivation of camelpox virus in chick embryos. In: Virusnye Bolezni Selskokhozyaystvenykh Zhivotnykh Part I (In Russian). Moscow; 1970. p. 55.

  76. 76.

    Sheikh Ali HM, Khalafalla AI, Nimir AH. Detection of Camelpox and vaccinia viruses by polymerase chain reaction. Trop Anim Health Prod. 2009;41(8):1637–41.

    PubMed  Article  Google Scholar 

  77. 77.

    Singh RK, Balamurugan V, Hosamani M, Kallesh DJ, Bhanuprakash V. Sequence analysis of C18L gene of Buffalopox virus: PCR strategy for specific detection and its differentiation from orthopoxviruses. J Virol Methods. 2008;154(1–2):146–53.

    PubMed  Article  CAS  Google Scholar 

  78. 78.

    Smee DF. Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antiviral Chem Chemother. 2008;19:115–24.

    CAS  Google Scholar 

  79. 79.

    Smith GL, Symons JA, Alcamı A. Poxviruses; interfering with interferon. Sem Virol. 1992;8:409–18.

    Article  Google Scholar 

  80. 80.

    Snoeck R, Andrei G, De Clercq E. Therapy of poxvirus infections. In: Mercer AA, Schmidt A, Weber O, editors. Poxviruses. Basel: Birkhauser; 2007. p. 375–95.

    Chapter  Google Scholar 

  81. 81.

    Tantawi HH, El Dahaby H, Fahmy LS. Comparative studies on poxvirus strains isolated from camels. Acta Virol. 1978;22:451–7.

    PubMed  CAS  Google Scholar 

  82. 82.

    Turner PC, Musy PY, Moyer RW. Poxvirus serpins. In McFadden G, Austin, Landes RG, editors. Viroceptors, Virokines and related immune modulators encoded by DNA Viruses. TX, USA: RG Landes; 1995. p. 67–88.

  83. 83.

    Venkatesan G, Balamurugan V, Hasamani M, Singh RK, Bhanuprakash V. Multiplex PCR for detection and differentiation of pox viruses, New letter. Indian Veterinary Research Institute, Izatnagar, UP, India, 2009. 30 (2)–31 (1): 1–2.

  84. 84.

    Venkatesan G, Bhanuprakash V, Balamurugan V, Prabhu M, Pandey AB. TaqMan hydrolysis probe based real time PCR for detection and quantitation of camelpox virus in skin scabs. J Virol Methods. 2012;181(2):192–6.

    PubMed  Article  CAS  Google Scholar 

  85. 85.

    Venkatesan G, Bhanuprakash V, Balamurugan V, Singh RK, Pandey AB. Development of loop-mediated isothermal amplification assay for specific and rapid detection of camelpox virus in clinical samples. J Virol Methods. 2012;183(1):34–9.

    PubMed  Article  CAS  Google Scholar 

  86. 86.

    Walter L, Marynen P, Szpirer J, Levan G, Gunther E. Identification of a novel conserved human gene, TEGT. Genomics. 1995;28:301–4.

    PubMed  Article  CAS  Google Scholar 

  87. 87.

    Wernery U, Kaaden OR, Ali M. Orthopox virus infections in dromedary camels in United Arab Emirates (UAE) during winter season. J Cam Pract Res. 1997;4(1):51–5.

    Google Scholar 

  88. 88.

    Wernery U, Kaaden OR. Camelpox. Infectious diseases in camelids, vol. 2nd Edn. Berlin: Blackwell; 2002. p. 176–85.

    Chapter  Google Scholar 

  89. 89.

    Wernery U, Kinne J, Zachariah R. Experimental camelpox infection in vaccinated and unvaccinated guanacos. J Camel Pract Res. 2000;7(2):153–7.

    Google Scholar 

  90. 90.

    Wernery U, Meyer H, Pfeffer M. Camelpox in the United Arab Emirates and its prevention. J Cam Pract Res. 1997;4(2):135–9.

    Google Scholar 

  91. 91.

    Wernery U, Zachariah R. Experimental camelpox infection in vaccinated and unvaccinated dromedaries. Zentralbl Veterinarmed B. 1999;46(2):131–6.

    PubMed  CAS  Google Scholar 

  92. 92.

    Yager JA, Scott DW, Wilcock BP. Viral diseases of the skin. In: Jubb KVF, Kennedy PC, Palmer N, editors. Pathology of domestic animals. 4th ed. San Diego: Academic Press; 1991. p. 629–44.

    Google Scholar 

  93. 93.

    Yang G, Pevear DC, Davies MH, Collett MS, Bailey T, Rippen S, Barone L, Burns C, Rhodes G, Tohan S, Huggins JW, Baker RO, Buller RL, Touchette E, Waller K, Schriewer J, Neyts J, DeClercq E, Jones K, Hruby D, Jordan R. An orally bioavailable anti poxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus challenge. J Virol. 2005;79:13139–49.

    PubMed  Article  CAS  Google Scholar 

  94. 94.

    Yousif AA, Al-Naeem AA, Al-Ali MA. A three-minute nonenzymatic extraction method for isolating PCR-quality camelpox virus DNA from skin. J Virol Methods. 2010;169(1):138–42.

    PubMed  Article  CAS  Google Scholar 

  95. 95.

    Yousif AA, Al-Naeem AA. Recovery and molecular characterization of live camelpox virus from skin 12 months after onset of clinical signs reveals possible mechanism of virus persistence in herds. Vet Microbiol. 2012;159:320–6.

    PubMed  Article  CAS  Google Scholar 

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Correspondence to Vinayagamurthy Balamurugan.

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Balamurugan, V., Venkatesan, G., Bhanuprakash, V. et al. Camelpox, an emerging orthopox viral disease. Indian J. Virol. 24, 295–305 (2013). https://doi.org/10.1007/s13337-013-0145-0

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Keywords

  • Camelpox virus
  • Biology
  • Epidemiology
  • Diagnosis
  • Prophylaxis
  • Control measures