Abstract
Background and Objective
Fufang Danshen formula, a famous Chinese patent medicine containing Salvia miltiorrhiza, Panax notoginseng and borneol, has been widely used in the treatment of coronary heart disease. The application is restricted by low bioavailability partly due to Panax notoginseng saponins (PNS) instability and low in vivo absorption. Thus, adhesive pellets were developed to improve bioavailability. The objectives of the present study were to evaluate the adhesive preparation by describing PNS’s plasma pharmacokinetics in vivo and compare adhesive micro pills with normal preparation.
Method
LC-MS/MS method was established to analyze five ingredients, notoginsenoside R1 (R1), ginsenoside Rg1 (Rg1), ginsenoside Rb1 (Rb1), ginsenoside Re (Re), and ginsenoside Rd (Rd), in rats’ plasma to describe the pharmacokinetic parameters of PNS.
Results
The pharmacokinetic parameters were significantly different after oral administration three formulations. The results show adhesive formulations are superior to Fufang Danshen tablet (FDT); there are differences between the two adhesive, but not obvious.
Conclusions
It was found that the modification with adhesive materials improved PNS bioavailability in Fufang Danshen formula. These findings provide a way for further in vivo evaluation of different formulations.
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Funding
The project was supported by the National Science and Technology Major Project of China (No. 2014ZX09301306-008).
Conflict of interest
Xiao-nan Chen, Dan-qi Li, Meng-di Zhao, Gang-yan Yu, Shou-Ying Du, Yang Lu, Jie Bai, Peng-yue Li declare that they have no conflict of interest.
Ethical approval
The experimental design was approved by Beijing University of Chinese Medicine Committee on Animal Care and Use and the study was performed in accordance with the Internal Charter on the Humane Care and Use of Laboratory Animals.
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Chen, Xn., Li, Dq., Zhao, Md. et al. Pharmacokinetics of Panax notoginseng Saponins in Adhesive and Normal Preparation of Fufang Danshen. Eur J Drug Metab Pharmacokinet 43, 215–225 (2018). https://doi.org/10.1007/s13318-017-0433-y
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DOI: https://doi.org/10.1007/s13318-017-0433-y