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Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs

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Abstract

The present study was conducted to investigate the effects of some commonly used herbs namely Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on the pharmacokinetics of sildenafil in beagle dogs. The study design involved four treatments in a non-balanced crossover design. Sildenafil was given one tablet 100 mg orally to each dog and blood samples were obtained. After a suitable washout period, animals were commenced on a specific herb treatment for 1 week. Blood samples were withdrawn at different time intervals and sildenafil was analyzed by HPLC method. Oral administration of Nigella sativa resulted in reduction of AUC0–∞, C max and t 1/2 as compared to the control. Treatment of Lepidium sativum resulted in a significant reduction in the C max and AUC. There were no significant differences between the rests of the pharmacokinetic parameters relative to those of the control. For Trigonella foenum-graecum, the effects were similar to those obtained in case of Lepidium sativum. It was concluded that concurrent use of investigated herbs alters the pharmacokinetics of sildenafil. Co-administration of investigated herbs should be cautious since their concomitant use might result in decrease in sildenafil bioavailability.

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Acknowledgment

This study was supported by the Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia (Grant number: DSR-AR-2-20).

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The authors report no declarations of interest.

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Authors and Affiliations

  1. Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

    Abdullah M. Al-Mohizea, Abdul Ahad, Fahad I. Al-Jenoobi & Saleh A. Al-Suwayeh

  2. Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia

    Khalid M. AlKharfy

  3. Biomarkers Research Program, King Saud University, Riyadh, 11451, Saudi Arabia

    Khalid M. AlKharfy

  4. Department of Pharmaceutical Technology, College of Pharmacy, University of Tanta, Tanta, Egypt

    Gamal M. El-Maghraby

Authors
  1. Abdullah M. Al-Mohizea
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  2. Abdul Ahad
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  3. Gamal M. El-Maghraby
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  4. Fahad I. Al-Jenoobi
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  5. Khalid M. AlKharfy
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  6. Saleh A. Al-Suwayeh
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Correspondence to Abdul Ahad.

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Al-Mohizea, A.M., Ahad, A., El-Maghraby, G.M. et al. Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs. Eur J Drug Metab Pharmacokinet 40, 219–224 (2015). https://doi.org/10.1007/s13318-014-0199-4

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  • DOI: https://doi.org/10.1007/s13318-014-0199-4

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