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Laboratory Associations With Transcranial Doppler Categories in Sickle Cell Disease

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References

  1. Mahmoud AA, Abd El Hady NMS, Rizk MS, El-Hawwary AM, Saleh NY. MTHFR C677T polymorphism, plasma homocysteine, and pdgf-aa levels and transcranial doppler velocity in children with sickle cell disease. Indian Pediatr. 2023: 60:651–4.

    PubMed  Google Scholar 

  2. Hyacinth HI, Gee BE, Adamkiewicz TV, et al. Plasma BDNF and PDGF-AA levels are associated with high TCD velocity and stroke in children with sickle cell anemia. Cytokine. 2012; 60:302–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Ames PRJ, Arcaro A, Caruso M, Graf M, Marottoli V, Gentile F. Relevance of plasma homocysteine and methylenetetrahydrofolate reductase 677TT genotype in sickle cell disease: a systematic review and meta-analysis. Int J Mol Sci. 2022;23: 14641.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Prengler M, Sturt N, Krywawych S, Surtees R, Liesner R, Kirkham F. Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: a potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood. Dev Med Child Neurol. 2001;43:220–5.

    Article  CAS  PubMed  Google Scholar 

  5. Helantera I, Loginov R, Koskinen P, Tornroth T, Gronhagen-Riska C, Lautenschlager I. Persistent cytomegalovirus infection is associated with increased expression of TGF-betal, PDGF-AA and ICAM-1 and arterial intimal thickening in kidney allografts. Nephrol Dial Transplant. 2005;20:790–6.

    Article  PubMed  Google Scholar 

  6. Westphal M, Lautenschlager I, Backhaus C, et al. Cytomegalovirus and proliferative signals in the vascular wall of CABG patients. Thorac Cardiovasc Surg. 2006;54:219–26.

    Article  CAS  PubMed  Google Scholar 

  7. Adams RJ, McKie VC, Carl EM, et al. Long-term stroke risk in children with sickle cell disease screened with transcranial Doppler. Ann Neurol. 1997;42:699–704.

    Article  CAS  PubMed  Google Scholar 

  8. Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339:5–11.

    Article  CAS  PubMed  Google Scholar 

  9. Ware RE, Davis BR, Schultz WH, et al. Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD with transfusions changing to hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial. Lancet. 2016;387:661–70.

    Article  CAS  PubMed  Google Scholar 

  10. Abdullahi SU, Jibir BW, Bello-Manga H, et al. Hydroxyurea for primary stroke prevention in children with sickle cell anaemia in Nigeria (SPRING): a double-blind, multicentre, randomised, phase 3 trial. Lancet Haematol. 2022;9:e26–e37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hyacinth HI, Adams RJ, Voeks JH, Hibbert JM, Gee BE. Frequent red cell transfusions reduced vascular endothelial activation and thrombogenicity in children with sickle cell anemia and high stroke risk. Am J Hematol. 2014;89:47–51.

    Article  CAS  PubMed  Google Scholar 

  12. Elkind MS, Hills NK, Glaser CA, et al. Herpesvirus infections and childhood arterial ischemic stroke: results of the VIPS study. Circulation. 2016;133:732–41.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Grose C, Shaban A, Fullerton HJ. Common features between stroke following varicella in children and stroke following herpes zoster in adults: varicella-zoster virus in trigeminal ganglion. Curr Top Microbiol Immunol. 2023;438:247–72.

    PubMed  Google Scholar 

  14. Hutanu A, Iancu M, Maier S, Balasa R, Dobreanu M. Plasma biomarkers as potential predictors of functional dependence in daily life activities after ischemic stroke: a single center study. Ann Indian Acad Neurol 2020;23:496–503.

    Article  PubMed  Google Scholar 

  15. Cui Y, Wang XH, Zhao Y, Chen SY, Sheng BY, Wang LH, et al. Association of serum biomarkers with early neurologic improvement after intravenous thrombolysis in ischemic stroke. PLoS One. 2022;17:e0277020.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Yildirim O, Bicer A, Ozkan A, Kurtkaya O, Cirakoglu B, Kilic T. Expression of platelet-derived growth factor ligand and receptor in cerebral arteriovenous and cavernous malformations. J Clin Neurosci. 2010;17:1557–62.

    Article  CAS  PubMed  Google Scholar 

  17. Yamamoto M, Aoyagi M, Fukai N, Matsushima Y, Yamamoto K. Differences in cellular responses to mitogens in arterial smooth muscle cells derived from patients with moyamoya disease. Stroke. 1998;29:1188–93.

    Article  CAS  PubMed  Google Scholar 

  18. Dlamini N, Saunders DE, Bynevelt M, et al. Nocturnal oxyhemoglobin desaturation and arteriopathy in a pediatric sickle cell disease cohort. Neurology. 2017;89:2406–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Jacob M, Stotesbury H, Kawadler JM, et al. White matter integrity in Tanzanian children with sickle cell anemia: a diffusion tensor imaging study. Stroke. 2020;51:1166–73.

    Article  PubMed  Google Scholar 

  20. Ganesan V, Prengler M, McShane MA, Wade AM, Kirkham FJ. Investigation of risk factors in children with arterial ischemic stroke. Ann Neurol. 2003;53:167–73.

    Article  PubMed  Google Scholar 

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Correspondence to Dipty Jain.

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Jain, D., Kirkham, F.J. Laboratory Associations With Transcranial Doppler Categories in Sickle Cell Disease. Indian Pediatr 60, 622–623 (2023). https://doi.org/10.1007/s13312-023-2957-3

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  • DOI: https://doi.org/10.1007/s13312-023-2957-3

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