Skip to main content
SpringerLink
Log in

Radiological Outcome of Neurocysticercosis in Children Six Months After Diagnosis — A Single Center Study

  • Research Paper
  • Published:
Indian Pediatrics Aims and scope Submit manuscript

Abstract

Objective

To assess proportion and predictors of lesion calcification in children aged 2–12 years with neurocysticercosis at six months follow up.

Method

Children aged between 2 and 12 years with Neurocysticercosis diagnosed on MRI brain were initially included and followed up for 6 months. Repeat CECT brain at 6 months was done to find if the lesion persisted/calcified/resolved.

Results

16 out of 30 patients (53.3%) had calcification at six months follow up. Perilesional edema at the initial stage of the presentation was significantly associated with calcification at 6 months (P=0.042).

Conclusion

Perilesional edema at the time of presentation was significantly associated with calcification in children with neurocysticercosis, six months after diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Reference

  1. Nash TE, Pretell EJ, Lescano AG, et al. Cysticercosis Working Group in Peru. Perilesional brain oedema and seizure activity in patients with calcified neurocysticercosis: a prospective cohort and nested case-control study. Lancet Neurol. 2008; 7: 1099–105.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Singh AK, Garg RK, Rizvi I, Malhotra HS, Kumar N, Gupta RK. Clinical and neuroimaging predictors of seizure recurrence in solitary calcified neurocysticercosis: a prospective observational study. Epilepsy Res. 2017; 137: 78–83.

    Article  PubMed  Google Scholar 

  3. Mahajan L, Malhotra HS, Garg RK et al. Predictors of lesion calcification in patients with solitary cysticercus granuloma and new-onset seizures. Am J Trop Med Hyg. 2016;95:623.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Gulati S, Jain P, Sachan D, et al. Seizure and radiological outcomes in children with solitary cysticercous granulomas with and without albendazole therapy: a retrospective case record analysis. Epilepsy Res. 2014;108:1212–20.

    Article  CAS  PubMed  Google Scholar 

  5. Sharma LN, Garg RK, Verma R, Singh MK, Malhotra HS. Seizure recurrence in patients with solitary cystic granuloma or single parenchymal cerebral calcification: a comparative evaluation. Seizure. 2013;22:840–5.

    Article  PubMed  Google Scholar 

  6. Lachuriya G, Garg RK, Jain A, et al. Toll-like receptor-4 polymorphisms and serum matrix metalloproteinase-9 in newly diagnosed patients with calcified neurocysticercosis and seizures. Medicine. 2016;95:1–7.

    Article  Google Scholar 

  7. Del Brutto OH, Nash TE, White Jr AC, et al. Revised diagnostic criteria for neurocysticercosis. J Neuro Sci. 2017; 372: 202–10.

    Article  CAS  Google Scholar 

  8. World Health Organization. WHO Child Growth Standards: length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: methods and development. World Health Organization; 2006.

  9. Khadilkar V, Yadav S, Agrawal KK, et al. Revised IAP Growth Charts for Height, Weight and Body Mass Index for 5- to 18-Year-Old Indian children. Indian Pediatr. 2015; 47–55.

  10. Kumar A, Mandal A, Sinha S, et al. Prevalence, response to cysticidal therapy, and risk factors for persistent seizure in Indian children with neurocysticercosis. Int J Pediatr. 2017; 2017: 1–6.

    Article  Google Scholar 

  11. Rao KS, Adhikari S, Gauchan E, et al. Time trend of neurocysticercosis in children with seizures in a tertiary hospital of western Nepal. PLoS Negl Trop Dis. 2017;11:1–11.

    Article  Google Scholar 

  12. Singhi P, Suthar R, Deo B, et al. Long-term clinical and radiologic outcome in 500 children with parenchymal neurocysticercosis. Pediatric Infect Dis J. 2017;36:549–55.

    Article  Google Scholar 

  13. Pretell EJ, Martinot Jr C, Garcia HH, et al. Cysticercosis Working Group in Peru. Differential diagnosis between cerebral tuberculosis and neurocysticercosis by magnetic resonance spectroscopy. J Comput Assist Tomogr. 2005; 29: 112–4.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, VMMC & Safdarjung Hospital, Delhi, 110029, India

    Parthiban Shanmugavel & Rachna Sehgal

  2. Department of Radiodiagnosis, VMMC and Safdarjung Hospital, New Delhi, India

    Ritu Nair Misra

Authors
  1. Parthiban Shanmugavel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rachna Sehgal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ritu Nair Misra
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rachna Sehgal.

Additional information

Ethics clearance

IEC, VM Medical College; No. IEC/VMMC/SJH/Thesis/2019-10/213, dated Oct 30, 2019.

Contributors

RS: Conceptualized and designed the study, supervised the data collection and helped in preparing manuscript; PS: Collected and analyzed the data and prepared the manuscript; RNM; Helped in designing the study and to collect data.

Funding

None

Competing interests

None stated.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shanmugavel, P., Sehgal, R. & Misra, R.N. Radiological Outcome of Neurocysticercosis in Children Six Months After Diagnosis — A Single Center Study. Indian Pediatr 60, 277–279 (2023). https://doi.org/10.1007/s13312-023-2858-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-023-2858-1

Keywords

Search

Navigation