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Comparison of Continuous Real Time Blood Glucose Measurement With Venous Laboratory Blood Glucose Level in Neonates During Perioperative Period



To compare the continuous real time blood glucose (CG) measurement with venous laboratory blood glucose (LG) level in neonates during perioperative period.


Glucose levels were measured simultaneously by CG, glucometer glucose (GG) and LG at 40 time points in ten neonates during perioperative period. Intraclass correlation coefficient (ICC) and Bland Altman analysis were used for comparison.


Correlation between CG and LG was excellent (ICC= 0.953; P<0.001), and average difference was 23.8 (95% CI 52.9 to −5.3) mg/dL, showed better reliability than at hyperglycemic state (ICC=0.653; P=0.006). The GG-LG showed excellent reliability with ICC = 0.985; P<0.001 and average difference of 15.4 (95% CI 30.7 to 0.1) mg/dL. CG at euglycemic state (ICC= 0.880; P<0.001).


CG measurement is reliable for blood sugar estimation in neonates; but has lower reliability for hyperglycemia. The continuous trend of glucose measurement by CG is helpful for timely diagnosis of hyperglycemia during perioperative period in neonates.

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Funding: None; Competing interests: None stated.

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Authors and Affiliations



Contributors: SKP: conceptualization, critical inputs to manuscript writing and supervision. MAW: principal investigator, data collection and writing manuscript. SSB: analysis and vital inputs to manuscript writing. SS: data collection and manuscript writing. All authors approved the final version of manuscript, and are accountable for all aspects related to the study.

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Correspondence to Santosh Kumar Panda.

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Ethics clearance: IEC, KIMS; No. KIMS/KIIT/IEC/799/2022 dated Jan 13, 2022.

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Wasiq, M.A., Behura, S.S., Sahoo, S. et al. Comparison of Continuous Real Time Blood Glucose Measurement With Venous Laboratory Blood Glucose Level in Neonates During Perioperative Period. Indian Pediatr 59, 620–622 (2022).

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