Abstract
This study was conducted to identify the mycological pattern, and to calculate the diagnostic accuracy of serum (1,3)-β-D-glucan for screening fungal sepsis in 351 high-risk neonates. Candida tropicalis was the most common isolate (n=16, 38.1%). At optimum cut-off (47.2 pg/mL), sensitivity and specificity of serum (1,3)-β-D-glucan were 92.9% and 69.9%, respectively.
This is a preview of subscription content, log in via an institution to check access.
References
Benjamin DK, Stoll BJ, Fanaroff AA, et al. Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. Pediatrics. 2006;117:84–92.
Makhoul IR, Kassis I, Smolkin T, et al. Review of 49 neonates with acquired fungal sepsis: further characterization. Pediatrics. 2001;107:61–6.
Jaijakul S, Vazquez JA, Swanson RN, et al. (1,3)-β-D-glucan as a prognostic marker of treatment response in invasive candidiasis. Clin Infect Dis. 2012;55:521–6.
Guo J, Wu Y, Lai W, et al. The diagnostic value of (1,3)-β-D-glucan alone or combined with traditional inflammatory markers in neonatal invasive candidiasis. BMC Infect Dis. 2019;19:716.
Mackay CA, Ballot DE, Perovic O. Serum 1,3-β-D-glucan assay in the diagnosis of invasive fungal disease in neonates. Pediatr Rep. 2011;3:e14.
Cotten CM, McDonald S, Stoll B, et al. The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. Pediatrics. 2006;118: 717–22.
Kumar R, Indrayan A. Receiver operating characteristic (ROC) curve for medical researchers. Indian Pediatr. 2011;48: 277–87.
Basu S, Kumar R, Tilak R, Kumar A. Candida blood stream infection in neonates: Experience from a tertiary care teaching hospital of central India. Indian Pediatr. 2017;54:556–9.
Juyal D, Sharma M, Pal S, et al. Emergence of non-albicans Candida species in neonatal candidemia. N Am J Med Sci. 2013;5:541–5.
Shabaan AE, Elbaz LM, El-Emshaty WM, et al. Role of serum (1,3)-β-d-glucan assay in early diagnosis of invasive fungal infections in a neonatal intensive care unit. J Pediatr (Rio J). 2018;94:559–65.
Funding
Funding: None
Author information
Authors and Affiliations
Contributions
KI: writing manuscript, collection of data, analysis of data; NK: collection of data, analysis of data, designing study; UM: writing and revising manuscript; KKD: collection of data, analysis of data; KN: planning study, revising manuscript. All authors approved the final version of manuscript.
Corresponding author
Ethics declarations
IEC, Burdwan Medical College; No. BMC-B-1058/C, dated July 11, 2017.
Additional information
Competing interest: None stated.
