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Low Osmolarity Oral Rehydration Salt Solution (LORS) in Management of Dehydration in Children
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Principles and Practice of Oral Rehydration

07 December 2019

Sylvia Y. Ofei & George J. Fuchs III

A double-blind clinical trial to compare the efficacy and safety of a multiple amino acid-based ORS with the standard WHO-ORS in the management of non-cholera acute watery diarrhea in infants and young children: “VS002A” trial protocol

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Rina Das, Rukaeya Amin Sobi, … Tahmeed Ahmed

Effect of Rehydration With Normal Saline Versus Ringer Lactate on Serum Sodium Level of Children With Acute Diarrhea and Severe Dehydration: A Randomized Controlled Trial

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Md Naseem, A. P. Dubey, … Raghvendra Singh

Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration

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Kirsty A. Houston, Jack Gibb, … Kathryn Maitland

Outcome of the use of 0.9% saline versus 0.45% saline for fluid rehydration in moderate and severe diabetic ketoacidosis in children

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Nora El Said Badawi, Mona Hafez, … Noha Arafa

A Half Century of Oral Rehydration Therapy in Childhood Gastroenteritis: Toward Increasing Uptake and Improving Coverage

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ESPNIC clinical practice guidelines: intravenous maintenance fluid therapy in acute and critically ill children— a systematic review and meta-analysis

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Parenteral Fluid Therapy in Children

22 May 2020

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0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to PICU—a randomized controlled trial (SPLYT-P): study protocol for an intravenous fluid therapy trial

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  • Published: 28 March 2021

Low Osmolarity Oral Rehydration Salt Solution (LORS) in Management of Dehydration in Children

  • Nimain Mohanty1,
  • Babu Ram Thapa2,
  • John Mathai3,
  • Uday Pai4,
  • Niranjan Mohanty5,
  • Vishnu Biradar6,
  • Pramod Jog7 &
  • …
  • Purnima Prabhu8 

Indian Pediatrics volume 58, pages 266–272 (2021)Cite this article

  • 473 Accesses

  • 1 Citations

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Abstract

Justification

The IAP last published the guidelines “Comprehensive Management of Diarrhea” in 2006 and a review in 2016. The WHO in 2002 and the Government of India in 2004 recommended low osmolarity rehydration solution (LORS) as the universal rehydration solution for all ages and all forms of dehydration. However, the use of LORS in India continues to be unacceptably low at 51%, although awareness about ORS has increased from a mere 14% in 2005 to 69% in 2015. Availability of different compositions of ORS and brands in market added to the confusion.

Process

The Indian Academy of Pediatrics constituted a panel of experts from the fields of pediatrics, pediatric gastroenterology and nutrition to update on management of dehydration in children with particular reference to LORS and issue a current practice guideline. The committee met twice at CIAP HQ to review all published literature on the aspect. Brief presentations were made, followed by discussions. The draft paper was circulated by email. All relevant inputs and suggestions were incorporated to arrive at a consensus on this practice guideline.

Objectives

To summarize latest literature on ORT and empower pediatricians, particularly those practicing in rural areas, on management of dehydration by augmenting LORS use.

Recommendations

It was stressed that advantages of LORS far out-weigh its limitations. Increased use of LORS can only be achieved by promoting better awareness among public and health-care providers across all systems of medicine. LORS can also be useful in managing dehydration in non-diarrheal illness. More research is required to modify ORS further to make it safe and effective in neonates, severe acute malnutrition, renal failure, cardiac and other co-morbidities. There is an urgent need to discourage production and marketing all forms of ORS not in conformity with WHO approved LORS, under a slogan “One India, one ORS”.

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Author information

Authors and Affiliations

  1. Department of Paediatrics, MGM Medical College, Kamothe, Navi Mumbai, Maharashtra, 410209, India

    Nimain Mohanty

  2. Department of Gastroenterology, Liver and Nutrition, PGIMER, Chandigarh, India

    Babu Ram Thapa

  3. Consultant in Pediatric GE, Masonic Children’s Hospital, Coimbatore, India

    John Mathai

  4. Consultant Pediatrician, Chembur, Mumbai, India

    Uday Pai

  5. Department of Pediatrics, KIMS, Bhubaneswar, Odisha, India

    Niranjan Mohanty

  6. Department of Pediatrics, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India

    Vishnu Biradar

  7. Department of Pediatrics, DY Patil Medical College, Pune, Maharashtra, India

    Pramod Jog

  8. Pediatric Nutritionist, P.D. Hinduja Hospital, Mumbai, Maharashtra, India

    Purnima Prabhu

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  1. Nimain Mohanty
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  2. Babu Ram Thapa
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  3. John Mathai
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  8. Purnima Prabhu
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Corresponding author

Correspondence to Nimain Mohanty.

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Competing interests

None stated

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Cite this article

Mohanty, N., Thapa, B.R., Mathai, J. et al. Low Osmolarity Oral Rehydration Salt Solution (LORS) in Management of Dehydration in Children. Indian Pediatr 58, 266–272 (2021). https://doi.org/10.1007/s13312-021-2168-8

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  • Published: 28 March 2021

  • Issue Date: March 2021

  • DOI: https://doi.org/10.1007/s13312-021-2168-8

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Keywords

  • Diarrhea
  • Management
  • Oral rehydration therapy
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