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Measles Specific Immunoglobulin G Response in Children Aged 4–12 Year Who Received Two Doses of Measles Containing Vaccine in Infancy

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Abstract

Objectives

To study the vaccine-induced measles specific immunoglobulin G (IgG) response in children aged 4–12 years immunized with two doses of measles containing vaccine in infancy.

Methods

This cross-sectional study was done in a tertiary care centre for a period of 18 months from January, 2017. Measles specific IgG levels were assessed using ELISA technique in 80 children of age 4–12 years, [mean (SD) age, 7.5 (2065)] who had received two doses of measles vaccine in infancy. Measles-specific IgG levels >11 NTU were considered protective.

Results

Protective levels of measles specific IgG were found in 86.4%. Significant association was found between negative immune response to measles vaccine and low socioeconomic status (P=0.03), under-nutrition (P=0.001), anemia (P=0.03), lack of exclusive breast feeding till 5 months of age (P=0.007) and higher parity (P=0.002).

Conclusion

Less than one-seventh of children immunized with two doses of measles vaccine in infancy had measles-specific IgG below protective levels at the average age of 7.5 yr. Lack of exclusive breast feeding till 5 months of age, under-nutrition and anemia were the associated factors.

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References

  1. World Health Organization: New Measles Surveillance Data for 2019. Accesses August 15, 2019. Available from: http://www.who.int/immunization/newsroom/measles-data-2019/en/

  2. Patel MK, Orenstein WA. Classification of global measles cases in 2013–17 as due to policy or vaccination failure: A retrospective review of global surveillance data. Lancet Glob Health. 2019;3:313–20.

    Article  Google Scholar 

  3. Melissa M, Coughlin, Andrew S, Beck, Bankamp B, Rota PA. Perspective on global measles epidemiology and control and the role of novel vaccination strategies. Viruses. 2017;9:11.

    Article  Google Scholar 

  4. Vashishtha VM, Yewale VN, Bansal CP, Mehta PJ. IAP perspectives on measles and rubella elimination strategies. Indian Pediatr. 2014;51:719–22.

    Article  Google Scholar 

  5. Gomber S, Arora SK, Das S, Ramachandran VG. Immune response to second dose of MMR vaccine in Indian children. Indian J Med Res. 2011; 134:302–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Hansashree P, Verma S, Rawat A, Sankhyan N, Bharti B. Long-term seroprotection rates following second dose of measles as MMR vaccine at 15 months in Indian children. Indian Pediatr. 2018; 55:405–7.

    Article  CAS  Google Scholar 

  7. Torre GL, Saulle R, Unim B, et al. The effectiveness of measles mumps rubella vaccination in the prevention of paediatric hospitalization for targeted and untargeted infections: A retrospective cohort study. Hum Vaccin Immunother. 2017;13:1879–83.

    Article  Google Scholar 

  8. Kanga AJ, Kaggia S, Ongusi J, Lwembe RM. Seroprevalence and risk factors associated with measles outbreaks among children in Kwale, Lamu and Narok Counties in Kenya. J Hum Virol Retrovirol. 2014;5: 00172.

    Google Scholar 

  9. Kizito D, Tweyongyere R, Namatovu A, et al. Factors affecting the infant antibody response to measles immunisation in Entebbe-Uganda. BMC Public Health. 2013;13:619.

    Article  CAS  Google Scholar 

  10. Haralambieva IH, Kennedy RB, Ovsyannikova IG, Whitaker JA, Poland GA. Variability in humoral immunity to measles vaccine: New Developments. Trends Mol Med. 2015;21:789–801.

    Article  CAS  Google Scholar 

  11. Ovsyannikova IG, Pankratz S, Vierkant RA, Jacobson RN, Poland GA. Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine. J Infect Dis. 2006; 193:655–63.

    Article  CAS  Google Scholar 

  12. Morris SK, Awasthi S, Kumar R, et al. Measles mortality in high and low burden districts of India: Estimates from a nationally representative study of over 12,000 child deaths. Vaccine. 2013; 31:4655–61.

    Article  Google Scholar 

  13. Perry RT, Gacic Dobo M, Dabbagh A. Progress towards regional measles elimination worldwide. Morb Mortal Wkly Rep. 2014; 63:1034–8.

    Google Scholar 

  14. Vashishtha VM, Choudhury P, Kalra A, et al. Indian Academy of Pediatrics (IAP) Recommended Immunization Schedule for Children Aged 0 through 18 years — India, 2014 and Updates on Immunization. Indian Pediatr. 2014; 51:785–800.

    Article  Google Scholar 

  15. Haralambieva IH, Ovsyannikova IG, Shane Pankratz S, Jacobson RM, Poland GA. A large observational study to concurrently assess persistence of measles specific B-cell and T-cell immunity in individuals following two doses of MMR vaccine. Vaccine. 2011;29:4485–91.

    Article  CAS  Google Scholar 

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Acknowledgements

Dr Sara Jones PhD, and Dr John B Johnson PhD, Scientists, Rajiv Gandhi Institute of Biotechnology, Thiruvananthapuram for their meticulous help and support for the study.

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Authors and Affiliations

  1. Department of Paediatrics, SAT Hospital, Govt Medical College, Trivandrum, Kerala, India

    P. Leela Kumari & Alka Madhavan Kutty

Authors
  1. P. Leela Kumari
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  2. Alka Madhavan Kutty
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Corresponding author

Correspondence to P. Leela Kumari.

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Ethics clearance

Institutional ethics committee, Government Medical College, Thiruvananthapuram; No.01/26/2017/MCT dated January 6, 2017.

Contributors

LK: planned the study, literature search, involved in data collection and analysis, prepared the manuscript. AM: done the data collection, literature search and involved in data analysis.

Funding

None; Competing interests: None stated.

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Kumari, P.L., Kutty, A.M. Measles Specific Immunoglobulin G Response in Children Aged 4–12 Year Who Received Two Doses of Measles Containing Vaccine in Infancy. Indian Pediatr 58, 250–252 (2021). https://doi.org/10.1007/s13312-021-2165-y

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  • DOI: https://doi.org/10.1007/s13312-021-2165-y

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