Skip to main content

Advertisement

SpringerLink
Log in

Mumps Antibody Titer in MMR-Vaccinated and Vaccine Naïve Children at a Public Hospital in Delhi

  • Research Paper
  • Published:
Indian Pediatrics Aims and scope Submit manuscript

Abstract

Objective

To compare the mumps antibody titers in Measles-Mumps-Rubella (MMR)-vaccinated and vaccine naive children.

Methods

This cross-sectional study was conducted at a tertiary-care public hospital in Delhi from November, 2016 to April, 2018 among 78 healthy children (aged 16 month–12 years) attending the pediatric outpatient department. Serum IgG and IgM rubella antibodies were measured by ELISA for confirmation of MMR vaccination status. Qualitative determination of IgG mumps was done followed by quantitative determination in samples positive for IgG mumps antibodies.

Results

IgG mumps was present in 69.2% of study population, with seroprotective titers in 32% taking endpoint titer as 1:4. Among MMR vaccinated children, 41.1% were sero-protected and in MMR vaccine naïve children 9.1% were seroprotected for mumps.

Conclusion

Single dose of MMR vaccine does not provide effective (>90%) sero-conversion required for successful herd immunity to prevent mumps outbreak.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rubin S, Eckhaus M, Rennick LJ, Bamford CGG, Duprex WP. Molecular biology, pathogenesis and pathology of mumps virus. J Pathol. 2105;235:242–52.

    Article  Google Scholar 

  2. John TJ. An outbreak of mumps in Thiruvananthpuram district. Indian Pediatr. 2004;41:298–300.

    PubMed  Google Scholar 

  3. Saha I, Haldar D, Paul B, et al. An epidemiological investigation of mumps outbreak in a slum of Kolkata. J Commun Dis. 2012;44:29–36.

    PubMed  Google Scholar 

  4. Raut CG, Sinha DP, Jayaprakash H, Hanumiah H, Manjunatha MJ. Mumps disease outbreak in Davangere district of Karnataka, India. Indian J Med Microbiol. 2015;33: 378–82.

    Article  CAS  Google Scholar 

  5. National Centre for Disease Control. Infectious disease surveillance programme-Weekly outbreaks. Accessed on December 4, 2018. Available from: https://idsp.nic.in/index4.php?lang=1andlevel=0andlinkid=406andlid=3689

  6. Bhatnagar N, Kaur R, Gupta M, Sharma D. Introducing combined measles, mumps and rubella vaccine in Chandigarh, India: Issues and Concerns. Indian Pediatr. 2014;51:15–7.

    Article  Google Scholar 

  7. Vashishtha VM, Yadav S, Dabas A, et al. IAP Position Paper on Burden of Mumps in India and Vaccination Strategies. Indian Pediatr. 2015;52:505–14.

    Article  Google Scholar 

  8. Date AA, Kyaw MH, Rue AM, et al. Long-term persistence of mumps antibody after receipt of two Measles-Mumps-Rubella(MMR) vaccinations and antibody response after a third MMR vaccination among a university population. J Infect Dis. 2008;197:1662–8.

    Article  Google Scholar 

  9. World Health Organization. Immunization coverage. WHO 2018. Accessed April 3, 2018.Available from: http://www.who.int/mediacentre/factsheets/fs378/en/#

  10. Petola H, Kulkarni PS, Kapre SV, Paunio M, Jadhav SS, Dhere RM. Mumps outbreaks in Canada and the United States: Time for new thinking on mumps vaccines. Clin Infect Dis. 2007;45:459–66.

    Article  Google Scholar 

  11. Vaidya SR, Brown DW, Jin L, Samuel D, Andrews NBK. Development of a focus reduction neutralization test (FRNT) for detection of MuV neutralizing antibodies. J Virol Methods. 2010;163:153–56.

    Article  CAS  Google Scholar 

  12. Orvell C, Rydbeck R, Love A. Immunological relationships between mumps virus and parainfluenza viruses studied with monoclonal antibodies. J. Gen Virol. 1986;67:1929–39.

    Article  Google Scholar 

  13. Malaiyan J, Menon T. Low vaccine efficacy of mumps component among MMR vaccine recipients in Chennai, India. Indian J Med Res. 2014;139:773–5.

    PubMed  PubMed Central  Google Scholar 

Download references

Funding

None

Author information

Authors and Affiliations

  1. Department of Microbiology, University College of Medical Sciences and Guru TegBahadur Hospital, Delhi, India

    Bhoomika Saxena, V. G. Ramachandran & Rumpa Saha

  2. Department of Pediatrics, University College of Medical Sciences and Guru TegBahadur Hospital, Delhi, India

    Dheeraj Shah

  3. 105, Gaytri Nilaya, 12th B Main Road, 6th Block, Rajajinagar, Bengaluru, Karnataka, 560 010, India

    Bhoomika Saxena

Authors
  1. Bhoomika Saxena
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. G. Ramachandran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rumpa Saha
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dheeraj Shah
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

BS: Investigator, writing — original draft, review and editing; VGR: conceptualization and methodology; RS: project administration; DS: resources and supervision.

Corresponding author

Correspondence to Bhoomika Saxena.

Ethics declarations

Ethics clearance: Institutional Ethics Committee, UCMS; No. IEC-HR/130/18.10.2016 dated November 25, 2016.

Competing interests: None stated.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Saxena, B., Ramachandran, V.G., Saha, R. et al. Mumps Antibody Titer in MMR-Vaccinated and Vaccine Naïve Children at a Public Hospital in Delhi. Indian Pediatr 58, 137–139 (2021). https://doi.org/10.1007/s13312-021-2129-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-021-2129-2

Keywords

Search

Navigation