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Maternal Occupational Tobacco Exposure and Newborn Umbilical Cord Serum Leptin Concentration

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Abstract

Objective

To assess the effect of maternal occupational tobacco handling (bidi rolling) on cord serum leptin levels.

Methods

We enrolled 64 neonates born to women who were bidi-rollers, and 64 small for gestational age (SGA) neonates and 57 term appropriate for gestational age (AGA) neonates born to mothers with no tobacco exposure. Cord blood leptin levels between the groups were compared. Adjusted mean difference in leptin was calculated using regression model.

Results

Cord leptin showed moderate correlation with birthweight (r=0.16; P=0.027) across the groups. Mean (SD) cord serum leptin levels (ng/mL) of study group was 19.79 (13.32), in comparison to 21.4 (13.4) of SGA (P=0.497), and 27.70 (13.96) of term AGA (P=0.002). Maternal occupational tobacco exposure contributed to significant decrease in cord leptin (adjusted mean difference (95%CI): −4.5 ng/mL (−8.82, −0.19); P=0.041).

Conclusion

Maternal occupational tobacco exposure causes significant reduction in fetal leptin levels.

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References

  1. Jaquet D, Gaboriau A, Czernichow P, Levy-Marchal C. Relatively low serum leptin levels in adults born with intrauterine growth retardation. Int J Obes Relat Metab Disord. 2001;25:491–5.

    Article  CAS  PubMed  Google Scholar 

  2. Briffa JF, McAinch AJ, Romano T, Wlodek ME, Hryciw DH. Leptin in pregnancy and development: A contributor to adulthood disease? Am J Physiol Endocrinol Metab. 2015;308:e335–50.

    Article  CAS  PubMed  Google Scholar 

  3. Kayemba-Kay’s S, Geary MPP, Pringle J, Rodeck CH, Kingdom JCP, Hindmarsh PC. Gender, smoking during pregnancy and gestational age influence cord leptin concentrations in newborn infants. Eur J Endocrinol. 2008; 159: 217–24.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Mantzoros CS, Varvarigou A, Kaklamani VG, Beratis NG, Flier JS. Effect of birth weight and maternal smoking on cord blood leptin concentrations of full-term and preterm newborns. J Clin Endocrinol Metab. 1997;82:2856–61.

    CAS  PubMed  Google Scholar 

  5. National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. The Health Consequences of Smoking — 50 Years of Progress: A Report of the Surgeon General [Internet]. Atlanta (GA): Centers for Disease Control and Prevention (US); 2014. Available from: http://www.ncbi.nlm.nih.gov/books/NBK179276/. Accessed January 27, 2020.

  6. Fleisch AF, Rifas-Shiman SL, Rokoff LB, Hivert M, Mantzoros CS, Oken E. Associations of maternal prenatal smoking with umbilical cord blood hormones: The Project Viva Cohort. Metabolism. 2017;72:18–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Fang F, Luo ZC, Dejemli A, Delvin E, Zhang J. Maternal smoking and metabolic health biomarkers in newborns. PLoS One. 2015;10:e0143660.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Chelchowska M, Ambroszkiewicz J, Mazur J, Lewandowski L, Maciejewski TM, Oltarzewski M, et al. Effect of tobacco smoking on the maternal and fetal adipokine axis in relation to newborn birth weight and length. Przegl Lek. 2014;71:567–71.

    PubMed  Google Scholar 

  9. Pardo IM, Geloneze B, Tambascia MA, Barros-Filho AA. Does maternal smoking influence leptin levels in term, appropriate-for-gestational-age newborns? J Matern Fetal Neonatal Med. 2004;15:408–10.

    Article  CAS  PubMed  Google Scholar 

  10. Helland IB, Reseland JE, Saugstad OD, Drevon CA. Smoking related to plasma leptin concentration in pregnant women and their newborn infants. Acta Paediatr. 2001;90:282–7.

    Article  CAS  PubMed  Google Scholar 

  11. International Labour Organisation. Making ends meet: Bidi workers in India today. Study of four states. Geneva: International Labour Organisation; 2003. Available from: http://www.ilo.org/public/english/dialogue/sector/papers/food/wp202.pdf. Accessed Jan 25, 2020.

  12. Shenoy RD, Sindgikar SP, Shenoy V, Uppoor R, Rao R, Singh S. Pregnancy outcome in occupational tobacco exposure: A cohort study from South India. Indian J Community Med. 2020;45:54–9.

    Article  PubMed  PubMed Central  Google Scholar 

  13. American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5): 1122–31.

    Article  Google Scholar 

  14. Lubchenco LO, Hansman C, Boyd E. Intrauterine growth in length and head circumference as estimated from live births at gestational ages from 26 to 42 weeks. Pediatrics. 1966; 37:403–8.

    Article  CAS  PubMed  Google Scholar 

  15. Benowitz NL, Hukkanen J, Jacob P 3rd. Nicotine chemistry, metabolism, kinetics and biomarkers. Handb Exp Pharmacol. 2009;192:29–60.

    Article  CAS  Google Scholar 

  16. Stefaniak M, Dmoch-Gajzlerska E, Mazurkiewicz B, Gajzlerska-Majewska W. Maternal serum and cord blood leptin concentrations at delivery. PLoS One. 2019;14: e0224863.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

Dr P Nayan Baba, Dr B Balakrshina, Dr Mufeeda Alungal and Dr Arun Varghese for their help in data and cord blood collection.

Funding

Nitte deemed to be university Faculty research grant.

Author information

Authors and Affiliations

  1. Department of Pediatrics, KS Hegde Medical Academy, Nitte (deemed to be University), Mangalore, India

    Swathi S. Rao, Denya Mary Yeldho, Y. Sunil Kumar & Rathika D. Shenoy

  2. Department of Central Research Laboratory, KS Hegde Medical Academy, Nitte (deemed to be University), Mangalore, India

    A. Preethika

Authors
  1. Swathi S. Rao
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  2. A. Preethika
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  3. Denya Mary Yeldho
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  4. Y. Sunil Kumar
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  5. Rathika D. Shenoy
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Contributions

SSR, RDS: conceived and designed the study, involved in data analysis and writing the manuscript; AP, YSK: contributed in sample collection and conducted laboratory investigations. DMY contributed in data collection. All the authors were involved in critical appraisal of the manuscript.

Corresponding author

Correspondence to Rathika D. Shenoy.

Ethics declarations

Institutional ethics committee, K S Hegde Medical Academy; No. INST.EC/EC/53/2017-18, dated March 23, 2017.

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Competing interest

None stated.

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Rao, S.S., Preethika, A., Yeldho, D.M. et al. Maternal Occupational Tobacco Exposure and Newborn Umbilical Cord Serum Leptin Concentration. Indian Pediatr 57, 918–921 (2020). https://doi.org/10.1007/s13312-020-1995-3

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  • DOI: https://doi.org/10.1007/s13312-020-1995-3

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