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Progression of Thyrotropinemia in Overweight and Obese Children From Puducherry, India

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Abstract

Objective

To assess the progression of thyrotropinemia to overt hypothyroidism in overweight and obese children.

Methods

150 overweight and obese children aged 5–15 years were enrolled. Free T4 and thyroid stimulating hormone (TSH) were done at enrollment and for those with TSH >5 mIU/L, TSH levels were repeated after 1 year.

Results

The mean (SD) body mass index (BMI) and TSH were 23.8 (3.19) kg/m2 and 2.70 (2.44) mIU/L, respectively. 17 children had thyrotropinemia (TSH between 10–15mIU/L); 10 (84.6%) of these children attained normal TSH levels at one year follow-up, and none progressed to overt hypothyroidism (TSH >15 mIU/L).

Conclusion

Levels of 5–15 mIU/L are common in asymptomatic overweight and obese children. Majority of these children revert back to normal TSH levels on follow-up.

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Acknowledgement

Mrs Poovitha, Statistician, Indira Gandhi Medical College and Research Institute, Puducherry, India.

Funding

None

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Authors and Affiliations

  1. Departments of Pediatrics, Indira Gandhi Medical College and Research Institute (IGMC&RI), Puducherry, India

    Srinivasan Thiagarajan & Rajeshwar Balaji

  2. Departments of Pediatrics, All India Institute of Medical Sciences, Mangalagiri, Andhra Pradesh, 522 503, India

    Thirunavukkarasu Arun Babu

Authors
  1. Srinivasan Thiagarajan
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  2. Thirunavukkarasu Arun Babu
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  3. Rajeshwar Balaji
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Contributions

ST,AT: conceived the study; ST, RB: collected data and managed the cases; ST,RB: reviewed the literature and drafted the initial version of the manuscript; AT contributed to literature review and critically revised the manuscript. All authors contributed to drafting of the manuscript and approved the final version of the manuscript.

Corresponding author

Correspondence to Thirunavukkarasu Arun Babu.

Ethics declarations

Institute Ethics committee IGMC&RI, Puducherry; No. 06/IEC/IGMC&RI/F-7/2018 dated June 6, 2018.

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Competing interests

None stated.

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Thiagarajan, S., Babu, T.A. & Balaji, R. Progression of Thyrotropinemia in Overweight and Obese Children From Puducherry, India. Indian Pediatr 57, 907–909 (2020). https://doi.org/10.1007/s13312-020-1991-7

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  • DOI: https://doi.org/10.1007/s13312-020-1991-7

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