Abstract
To estimate the time trend and prevalence of celiac disease in 208 children with type 1 diabetes by retrospective case review. Tissue transglutaminase (TTG IgA) levels were done within the first six months of diagnosis and annually on follow-up. Celiac disease was diagnosed in 35 (16.8%; 3 before diagnosis, 18 at initial screening and 14 on follow-up). 14 subjects with negative TTG serology at presentation, developed celiac disease after 3.9 (2.9) years (range 1.4–12.6 years, 85.7% within 5 years). Celiac disease is common in Indian children and adolescents with type I diabetes, developing in most within five years of diagnosis.
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Contributors: NA,CD,RP: data collection; NA: literature review, statistical analysis and drafted the initial manuscript; RS,AB: patient management; AB: conceptualized and planned the study, conducted statistical analysis, critically reviewed the manuscript and would act as guarantor of the paper.
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Ethical clearance: Regency Hospital Limited; RHL-IEC-16035 dated September 11, 2019.
Competing interest: None stated.
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Agarwal, N., Dave, C., Patel, R. et al. Celiac Disease in Indian Children and Adolescents with Type 1 Diabetes. Indian Pediatr 57, 750–752 (2020). https://doi.org/10.1007/s13312-020-1923-6
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DOI: https://doi.org/10.1007/s13312-020-1923-6