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Serum Presepsin, Proadrenomedullin and Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as Biomarkers for the Diagnosis of Acute Pyelonephritis

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Abstract

Objective

To investigate the diagnostic values of serum presepsin, proadrenomedullin (proADM) and triggering receptor expressed on myeloid cells-1 (TREM-1) levels in children with acute pyelonephritis and lower urinary tract infection.

Methods

Peripheral venous blood and urine samples were obtained before starting antibiotic therapy at the time of admission in all patients. Serum TREM-1, presepsin and proADM concentrations were determined by the enzyme-linked immunosorbent assay method.

Results

82 children (38 acute pyelonephritis, 24 lower urinary tract infection, 20 controls) were enrolled. Serum proADM and TREM-1 levels were higher in patients with acute pyelonephritis than those of lower urinary tract infection and controls (P=0.001 and P<0.001, respectively). Both serum proADM and TREM-1 levels had predictive value for diagnosis of acute pyelonephritis (P=0.006 and P<0.001, respectively). ROC analysis showed that proADM and TREM-1 had positive predictive values for diagnosis of acute pyelonephritis (AUC=0.830, P=0.003; and AUC=0.843, P <0.001, respectively).

Conclusion

Serum proADM and TREM-1 levels could serve as early biomarkers for the diagnosis of acute pyelonephritis in children.

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Funding

Funding: None

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Faculty of Medicine, Eskisehir Osmangazi University, TR-26480, Eskisehir, Turkey

    Nuran Cetin & Aylin Gencler

  2. Department of Biochemistry, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey

    Zeynep Kusku Kiraz

Authors
  1. Nuran Cetin
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  2. Zeynep Kusku Kiraz
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  3. Aylin Gencler
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Contributions

Contributors: NC: concept, design, definition of intellectual content, protocol development, literature search, clinical studies, data acquisition, drafting the work, manuscript preparation, ZKK: design, definition of intellectual content, data acquisition, data analysis, drafting the work, AG: literature search, data acquisition, clinical studies, drafting the work. All authors approved the final manuscript submitted.

Corresponding author

Correspondence to Nuran Cetin.

Ethics declarations

Ethical approval: Eskisehir Osmangazi University Ethics Committee; No. 80558721/129 dated May 31, 2016.

Competing interest: None stated.

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Cetin, N., Kiraz, Z.K. & Gencler, A. Serum Presepsin, Proadrenomedullin and Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) as Biomarkers for the Diagnosis of Acute Pyelonephritis. Indian Pediatr 57, 715–718 (2020). https://doi.org/10.1007/s13312-020-1914-7

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  • DOI: https://doi.org/10.1007/s13312-020-1914-7

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