Skip to main content

Advertisement

Log in

GATA 2 Haploinsufficiency in Acute Myeloid Leukemia: Looking Beyond the Obvious

  • Clinical Case Letters
  • Published:
Indian Pediatrics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Mir MA, Kochuparambil ST, Abraham RS, Rodriguez V, Howard M, Hsu AP, et al. Spectrum of myeloid neoplasms and immune deficiency associated with germline GATA2 mutations. Cancer Med. 2015;4: 490–9.

    Article  CAS  Google Scholar 

  2. Spinner MA, Sanchez LA, Hsu AP, Shaw PA, Zerbe CS, Calvo KR, et al. GATA2 deficiency: A protean disorder of hematopoiesis, lymphatics, and immunity. Blood. 2014; 123:809–21.

    Article  CAS  Google Scholar 

  3. Wlodarski MW, Hirabayashi S, Pastor V, Starý J, Hasle H, Masetti R, et al. Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents. Blood. 2016;127: 1387–97.

    Article  CAS  Google Scholar 

  4. Collin M, Dickinson R, Bigley V. Haematopoietic and immune defects associated with GATA2 mutation. Br J Haematol. 2015;169:173–87.

    Article  CAS  Google Scholar 

  5. Rastogi N, Abraham RS, Chadha R, Thakkar D, Kohli S, Nivargi S, et al. Successful nonmyeloablative allogeneic stem cell transplant in a child with emberger syndrome and GATA2 mutation. J Pediatr Hematol Oncol. 2018;40: e383–8.

    Article  Google Scholar 

  6. Vinh DC, Patel SY, Uzel G, Anderson VL, Freeman AF, Olivier KN. Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia. Blood. 2010;115: 1519–29.

    Article  CAS  Google Scholar 

Download references

Funding

None

Author information

Authors and Affiliations

Authors

Contributions

NR: diagnosis and management; SS,DN,JM: laboratory evaluation. All have contributed to the manuscript preparation and its approval.

Corresponding author

Correspondence to Nita Radhakrishnan.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Radhakrishnan, N., Singh, S., Nath, D. et al. GATA 2 Haploinsufficiency in Acute Myeloid Leukemia: Looking Beyond the Obvious. Indian Pediatr 57, 570–571 (2020). https://doi.org/10.1007/s13312-020-1858-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-020-1858-y

Navigation