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Factors Associated With Ovarian Preservation in Children and Adolescents With Primary Tumors of Ovary

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Abstract

Objective

To determine management of pediatric ovarian masses and identify the factors associated with ovarian preservation.

Methods

From January, 2002 to January, 2019 the case records of 72 patients (median age 14 y), who underwent surgery for ovarian tumors were retrospectively reviewed.

Results

Tumors were most common in the age group 14’17 yrs (58.3%) and most (91.7%) were benign. The most common presenting symptom was abdominal pain (80.5%) followed by vomiting, elevated body temperature, nausea and palpable abdominal mass. 25 (34.7%) patients had an ovarian torsion. Six out of 72 (8.3%) patients had malignant tumors. Of the patients with malignant tumors, 75% had abnormal alpha-fetoprotein and 50% had abnormal β-human chorionic gonadotropin levels (P<0.001). Ovarian-preserving surgery was successfully performed in 74.3% of the benign lesions and two patients (25%) with malignant tumors (P=0.004).

Conclusions

Factors associated with ovarian-preserving surgery are benign tumor, normal tumor markers levels, and smaller size of tumor.

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Authors and Affiliations

  1. Department of Pediatric Surgery, School of Medicine, Soltanska 2, 21 000, Split, Croatia

    Zenon Pogorelic & Miro Jukic

  2. School of Medicine, University of Split, Soltanska 2, 21 000, Split, Croatia

    Zenon Pogorelic, Doroteja Jukic & Ivana Mrklic

  3. Department of Pathology, University Hospital of Split, Spinciceva 1, 21 000, Split, Croatia

    Ivana Mrklic

Authors
  1. Zenon Pogorelic
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  2. Doroteja Jukic
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  3. Miro Jukic
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  4. Ivana Mrklic
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Contributions

ZP: concept and designed the study, analyzed data; DJ: collected the data and helped in data analysis and drafted the manuscript; MJ: collected the data, drafted the manuscript and revised manuscript critically; IM: data analysis, drafted the manuscript, supervised and revised manuscript critically for important intellectual content. All authors approved the final version of manuscript, and are accountable for all aspects related to the study.

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Correspondence to Zenon Pogorelic.

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Pogorelic, Z., Jukic, D., Jukic, M. et al. Factors Associated With Ovarian Preservation in Children and Adolescents With Primary Tumors of Ovary. Indian Pediatr 57, 515–518 (2020). https://doi.org/10.1007/s13312-020-1847-1

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  • DOI: https://doi.org/10.1007/s13312-020-1847-1

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