Abstract
Background
Maternal urinary iodine concentration (MUIC) and percentage of neonates with Thyroid stimulating hormone (TSH) >5 mIU/L are amongst the parameters suggested for assessing adequate iodine status.
Objective
To assess the correlation between MUIC and neonatal TSH levels.
Study design
Cross-sectional.
Settings
Tertiary care center in Delhi, India, between November 2015 to November 2016.
Participants
Postnatal mother-neonate dyads.
Methods
TSH levels assessed among neonatal samples were stratified as below and above 5 mIU/L. MUIC was measured in 544 mothers, 400 mother-neonate dyads with neonatal TSH levels >5 mIU/L (cases) and 144 mother-neonate newborn mother dyads with neonatal TSH <5 mIU/L (controls).
Results
The percentage of mothers with iodine insufficiency (9.8% vs 5.6%) as well as iodine excess (54.3% vs 41.7%) were significant higher in cases than controls. Mean TSH was also higher (P=0.0002) in both the iodine deficient and iodine excess group. There was no correlation between neonatal TSH values and MUIC.
Conclusions
Lack of correlation between neonatal TSH and MUIC is due to iodine excess together with iodine deficiency.
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Funding
Funding: Science and Engineering Research Board, New Delhi for NBS study in Delhi state vide Grant # IR/SO/LC-0001/2012.
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Sait, H., Kapoor, S., Jindal, A. et al. Association Between Neonatal Thyroid Stimulating Hormone Status and Maternal Urinary Iodine Status. Indian Pediatr 56, 472–475 (2019). https://doi.org/10.1007/s13312-019-1571-x
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DOI: https://doi.org/10.1007/s13312-019-1571-x