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Gallbladder Disease in Children: A 20-year Single-center Experience

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Aim of this study was to examine the changes in incidence of pediatric cholecystectomies.


Based on a review of hospital-records, children were divided into two groups regarding year of surgery (Group I: 1998–2007; Group II: 2008–2017) and their characteristics were compared.


Number of cholecystecomies increased from 11 to 34. Median age increased from 11 to 15.5 years and mean BMI increased from 19.2 kg/m2 to 23.0 kg/m2. Hereditary spherocytosis decreased from 63.6% to 11.8% (P=0.001) of indications for cholecystectomy, while proportion of cholesterol stones increased from 27.3% to 70.6% (P=0.006). Frequency of laparoscopic cholecystectomy increased from 36.4% to 85.3% (P=0.001). Duration of hospital stay shortened from 8to 4 days (P=0.008).


Number of pediatric cholecystectomies has significantly increased in the last 20 years, as well as average BMI of the observed population This probably signifies a correlation between rising obesity rates and increase in frequency of symptomatic cholelithiasis in children.

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  1. Peric B, Perko Z, Pogorelic Z, Kraljevic J. Laparoscopic cholecystectomy in Cantonal Hospital Livno, Bosnia and Herzegovina and University Hospital Center Split, Croatia. Coll Antropol. 2010;34:125–8.

    PubMed  Google Scholar 

  2. Khoo AK, Cartwright R, Berry S, Davenport M. Cholecystectomy in English children: Evidence of an epidemic (1997–2012). J Pediatr Surg. 2014;49:284–8.

    Article  PubMed  Google Scholar 

  3. Rothstein DH, Harmon CM. Gallbladder disease in children. Semin Pediatr Surg. 2016;25:225–31.

    Article  PubMed  Google Scholar 

  4. Tuna Kirsaclioglu C, Cuhaci Cakir B, Bayram G, Akbiiik F, Isik P, Tunc B. Risk factors, complications and outcome of cholelithiasis in children: A retrospective, single-center review. J Paediatr Child Health. 2016;52:944–9.

    Article  PubMed  Google Scholar 

  5. Campbell S, Richardson B, Mishra P, Wong M, Samarkkody U, Beasley S, et al. Childhood cholecystectomy in New Zealand: A multicenter national 10 year perspective. J Pediatr Surg. 2016;51:264–7.

    Article  PubMed  Google Scholar 

  6. Waldhausen JHT, Benjamin DR. Cholecystectomy is becoming an increasingly common operation in children. Am J Surg. 1999;177:364–7.

    Article  CAS  PubMed  Google Scholar 

  7. Murphy PB, Vogt KN, Winick-Ng J, McClure JA, Welk B, Jones SA. The increasing incidence of gallbladder disease in children: A 20-year perspective. J Pediatr Surg. 2016;51:748–52.

    Article  PubMed  Google Scholar 

  8. Bogue CO, Murphy AJ, Gerstle JT. Risk factors, complications, and outcomes of gallstones in children: A single-center review. J Pediatr Gastroenterol Nutr. 2010;50:303–8.

    Article  PubMed  Google Scholar 

  9. Mehta S, Lopez M, Chumpitazi B. Clinical characteristics and risk factors for symptomatic pediatric gallbladder disease. Pediatrics. 2012;129:82–8.

    Article  Google Scholar 

  10. Walker SK, Maki AC, Cannon RM, Foley DS, Wilson KM, Galganski LA, et al. Etiology and incidence of pediatric gallbladder disease. Surgery. 2013;154:927–31.

    Article  PubMed  Google Scholar 

  11. Kleiner O, Ramesh J, Huleihel M, Cohen B, Kantarovich K, Levi C, et al. A comparative study of gallstones from children and adults using FTIR spectroscopy and fluorescence microscopy. BMC Gastroenterol. 2002;2:3.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Stringer MD, Taylor DR, Soloway RD. Gallstone composition: Are children different? J Pediatr. 2003;142:435–40.

    Article  CAS  PubMed  Google Scholar 

  13. Rescorla FJ, Grosfeld JL. Cholecystitis and cholelithiasis in children. Sem Pediatr Surg. 1992;1:98–106.

    CAS  Google Scholar 

  14. Bailey PV, Connors RH, Tracy TJ Jr, Sotelo-Avila C, Lewis JE, Weber TR. Changing spectrum of cholelithiasis and cholecystitis in infants and children. Am J Surg. 1989;158:585–8.

    Article  CAS  PubMed  Google Scholar 

  15. Holcomb GW Jr, Holcomb GW III. Cholelithiasis in infants, children, and adolescents. Pediatr Rev. 1990;11:268–74.

    Article  PubMed  Google Scholar 

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Correspondence to Zenon Pogorelic.

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Pogorelic, Z., Aralica, M., Jukic, M. et al. Gallbladder Disease in Children: A 20-year Single-center Experience. Indian Pediatr 56, 384–386 (2019).

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