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Association of TLR4 and TNF-α Gene Polymorphisms and TLR4 mRNA Levels in Preterm Birth in a Northern Indian Population

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Abstract

Objective

To assess the association of TLR4 (rs4986790 and rs4986791) and TNF-α (rs1800629) genes polymorphisms and TLR4mRNA levels with preterm birth.

Methods

Hospital-based case-control study on women of Caucasoid morphological subtype ethnicity in Northern India. Inclusion criteria for cases: women aged between 18–40 years with preterm birth (<37 weeks gestation), and for controls: women who delivered a term neonate consecutive to an enrolled case. Three polymorphisms TLR4 (Asp299 Gly, Thr399 Ill) and TNF-á (-308G/A) and TLR4 mRNA levels were compared between cases and controls.

Results

From 2012–2015, 559 cases and 559 controls were recruited. TLR4 mRNA levels were found to be higher (P<0.001) in cases [(0.7 (0.04)] than in controls [(0.5 (0.04)]. No association was found between TLR4 Asp299 Gly, TLR4 Thr399 Ill and TNF-α (-308G/A) with preterm birth.

Conclusion

Increased TLR4 mRNA levels seem to be associated with preterm birth, and can be investigated further as a potential biomarker for identifying women at risk.

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Authors and Affiliations

  1. Departments Pediatrics, King George’s Medical College University, Lucknow, Uttar Pradesh, India

    Shally Awasthi & Monika Pandey

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  1. Shally Awasthi
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  2. Monika Pandey
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Correspondence to Shally Awasthi.

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Awasthi, S., Pandey, M. Association of TLR4 and TNF-α Gene Polymorphisms and TLR4 mRNA Levels in Preterm Birth in a Northern Indian Population. Indian Pediatr 56, 202–204 (2019). https://doi.org/10.1007/s13312-019-1500-z

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  • DOI: https://doi.org/10.1007/s13312-019-1500-z

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