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Prediction of Transient or Permanent Congenital Hypothyroidism from Initial Thyroid Stimulating Hormone Levels

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Abstract

Objective

To identify factors that discriminate between transient and permanent congenital hypothyroidism.

Methods

Retrospective evaluation of 58 children with congenital hypothyroidism and eutopic thyroid gland. Gender, gestational age, birth weight, TSH and serum thyroxine levels at diagnosis and L-thyroxine dose at 12 and 24 months of age were analyzed.

Results

Median (IQR) initial TSH levels were 73.3 (276.5) μIU/mL in permanent hypothyroidism and 24.24 (52.7) μU/mL in transient hypothyroidism (P =0.0132). The optimum cut-off value of initial TSH to predict transient hypothyroidism was 90 μIU/mL. Mean (SD) L-thyroxine doses at 24 months of age were 2.64 (0.98) μg/kg/day in permanent hypothyroidism and 1.91 (0.65) μg/kg/day in transient hypothyroidism. Requirement of Lthyroxine dose at 24 months of ≤0.94 μg/kg/day had the highest sensitivity (100%) to predict transient hypothyroidism.

Conclusions

L-thyroxine doses at 24 months can predict transient hypothyroidism in patients with eutopic thyroid gland earlier than at 36 months.

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Authors and Affiliations

  1. Unit of Pediatrics, Magna Graecia University of Catanzaro, Catanzaro, Italy

    Maria Scavone, Elena Carboni, Ettore Stefanelli, Giusy Romano, Laura Giancotti & Roberto Miniero

  2. Units of Laboratory Medicine, Catanzaro, Italy

    Anna Vero

  3. Pediatrics, Pugliese- Ciaccio Hospital, Catanzaro, Italy

    Valentina Talarico

  4. Unit of Pediatrics, Pugliese-Ciaccio Hospital, Viale Pio X, 88100, Catanzaro, Italy

    Valentina Talarico

Authors
  1. Maria Scavone
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  2. Elena Carboni
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  3. Ettore Stefanelli
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  4. Giusy Romano
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  5. Anna Vero
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  6. Laura Giancotti
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  7. Roberto Miniero
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  8. Valentina Talarico
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Corresponding author

Correspondence to Valentina Talarico.

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Scavone, M., Carboni, E., Stefanelli, E. et al. Prediction of Transient or Permanent Congenital Hypothyroidism from Initial Thyroid Stimulating Hormone Levels. Indian Pediatr 55, 1059–1061 (2018). https://doi.org/10.1007/s13312-018-1442-x

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  • DOI: https://doi.org/10.1007/s13312-018-1442-x

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