Abstract
Objective
To compare quality of life of children with thalassemia major who have undergone stem cell transplantation with those on regular transfusion.
Methods
The study included 40 children who underwent transplantation and 40 children and 20 adults on regular transfusion and iron chelation therapy. The quality of life assessment was done using the Pediatric Quality of Life Inventory 4.0 Generic Core Scale.
Results
The mean total summary score, psychosocial summary score and physical score was 92, 91 and 92.8, respectively in transplant group and 83, 82.7 and 83.6, respectively in children in transfusion group. The adult group on transfusion showed overall poorer scores of 74.9, 76 and 73.9, respectively. The average scores in all domains were significantly (P<0.05) lower and drop steeply in second decade in transfusion group.
Conclusion
Allogeneic stem cell transplantation improves quality of life in thalassemia major.
Similar content being viewed by others
References
Balgir RS. The burden of haemoglobinopathies in India and the challenges ahead. Curr Sci. 2000;79:1536–47.
Gaziev J, Sodani P, Lucarelli G. Hematopoietic stem cell transplantation in thalassemia. Bone Marrow Transpl. 2008;42:S41.
Varni JW, Burwinkle TM, Katz ER, Meeske K, Dickinson P. The PedsQL in pediatric cancer: Reliability and validity of the pediatric quality of life inventory generic core scales, mutidimensional fatigue scale, and cancer module. Cancer. 2002;94:2090–106.
Varni JW, Burwinkle TM, Seid M. The PedsQL 4.0 as a school population measure: Feasibility, reliability, and validity. Qual Life Res. 2006;15:203–15.
Lucarelli G, Galimberti M, Giardini C, Polchi P, Angelucci E, Baronciani D, et al. Bone marrow transplantation in thalassemia. The experience of Pesaro. Ann NY Acad Sci. 1998;850:270e5.
Ismail A, Campbell MJ, Ibrahim HM, Jones GL. Health related quality of life in Malaysian children with thalassaemia. Health Qual Life Outcomes. 2006;4:39.
Thavorncharoensap M, Torcharus K, Nuchprayoon I, Riewpaiboon A, Indaratna K, Ubol BO. Factors affecting health–related quality of life in Thai children with thalassemia. BMC Blood Disord. 2010;10:1.
Ansari SH, Baghersalimi A, Azarkeivan A, Nojomi M, Hassanzadeh Rad A. Quality of life in patients with thalassemia major. Iran J Ped Hematol Oncol. 2014;4:57–63.
Clarke SA, Skinner R, Guest J, Darbyshire P, Cooper J, Shah F, et al. Health–related quality of life and financial impact of caring for a child with thalassaemia major in the UK. Child Care Health Dev. 2010;36:118–22.
Cheuk DK, Mok AS, Lee AC, Chiang AK, Ha SY, Lau YL, et al. Quality of life in patients with transfusion–dependent thalassemia after hematopoietic SCT. Bone Marrow Transplant. 2008;42:319–27.
La Nasa G, Caocci G, Efficace F, Dessi C, Vacca A, Piras E, et al. Long–term health–related quality of life evaluated more than 20 years after hematopoietic stem cell transplantation for thalassemia. Blood. 2013;122:2262–70.
Chandy M. Stem cell transplantation in India. Bone Marrow Transplant. 2008;42:S81–4.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Patel, S., Swaminathan, V.V., Mythili, V.S. et al. Quality Matters–Hematopoietic Stem Cell Transplantation versus Transfusion and Chelation in Thalassemia Major. Indian Pediatr 55, 1056–1058 (2018). https://doi.org/10.1007/s13312-018-1441-y
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13312-018-1441-y