Skip to main content
Log in

Vitamin D Deficiency as a Factor Influencing Asthma Control in Children

Indian Pediatrics Aims and scope Submit manuscript

Cite this article

Abstract

Objective

To study the association between asthma control and serum 25OH Vitamin D levels in children with moderate persistent asthma on preventer therapy.

Methods

Children aged 6–18 years, with moderate persistent asthma, on preventer therapy for ≥2 months were included. Control was categorized as good, partial or poor as per GINA guidelines. Serum 25 (OH) Vitamin D levels were measured and their relationship with the level of control was studied.

Results

Out of 50 children enrolled, 22 had well-controlled asthma, and 21 had partially controlled asthma. Vitamin D was deficient in 30 children and insufficient in 18 children. Children with vitamin D deficiency had significantly less wellcontrolled asthma as compared to those with insufficient or sufficient levels of 25 (OH) vitamin D (13.3% vs 88.9 % vs 100%).

Conclusion

Vitamin D deficiency is associated with suboptimal asthma control.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. von Mutius E. The burden of childhood asthma. Arch Dis Child. 2000;82(S2):ii2–5.

    Google Scholar 

  2. Bossé Y, Maghni K, Hudson T. 1a, 25-Dihydroxyvitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes. Physiol Genomics. 2007;29:161–8.

    Article  CAS  PubMed  Google Scholar 

  3. Brehm J, Celedon J, Soto-Quiros M, Avila L, Hunninghake G, Forno E, et al. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med. 2009;179:765–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Global Strategy for Asthma Management and Prevention. Updated 2012 [Internet]. Global Initiative for Asthma (GINA); 2012 [cited 2013 Jun 27]. Available from: http://ginasthma.org. Accessed August 12, 2014.

  5. No authors listed. International Consensus Report on the Diagnosis and Management of Rhinitis. International Rhinitis Management Working Group. Allergy. 1994;49:1-34.

  6. Report of the Rhinosinusitis Task Force Committee Meeting. Alexandria, Virginia, August 17, 1996. Otolaryngol Head Neck Surg. 1997;117:S1-68.

  7. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2011; 96:1911–30.

    Article  CAS  PubMed  Google Scholar 

  8. Lindberg RE, Arroyave C. Levels of IgE in serum from normal children and allergic children as measured by an enzyme immunoassay. J Allergy Clin Immunol. 1986; 78:614–8.

    Article  CAS  PubMed  Google Scholar 

  9. Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, et al. Serum vitamin D levels and severe asthma exacerbations in the childhood asthma management program study. J Allergy Clin Immunol. 2010;126:52–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Chinellato I, Piazza M, Sandri M, Peroni D, Piacentini G, Boner AL. Vitamin D serum levels and markers of asthma control in Italian children. J Pediatr. 2011;158:437–41.

    Article  CAS  PubMed  Google Scholar 

  11. Kavitha TK, Gupta N, Kabra SK, Lodha R. Association of serum vitamin D levels with level of control of childhood asthma. Indian Pediatr. 2017;54:29–32.

    Article  CAS  PubMed  Google Scholar 

  12. Searing DA, Zhang Y, Murphy JR, Hauk PJ, Goleva E, Leung DY. Decreased serum vitamin D levels in children with asthma are associated with increased corticosteroid use. J Allergy Clin Immunol. 2010;125:995–1000.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr. 2004;80:1717S–20S.

    Article  CAS  PubMed  Google Scholar 

  14. May E, Asadullah K, Zugel U. Immunoregulation through 1,25-dihydroxyvitamin D3 and its analogs. Curr Drug Targets Inflamm Allergy. 2004;3:377–93.

    Article  CAS  PubMed  Google Scholar 

  15. Banerjee A, Damera G, Bhandare R, Gu S, Lopez-Boado Y, Panettieri R, et al. Vitamin D and glucocorticoids differentially module chemokine and glucocorticoids differentially modulate chemokine expressionin human airway smooth muscle cells. Br J Pharmacol. 2008; 155:84–92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Padmasani Venkat Ramanan.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kaaviyaa, A., Krishna, V., Arunprasath, T. et al. Vitamin D Deficiency as a Factor Influencing Asthma Control in Children. Indian Pediatr 55, 969–971 (2018). https://doi.org/10.1007/s13312-018-1420-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-018-1420-3

Keywords

Navigation