Indian Pediatrics

, Volume 55, Issue 1, pp 45–47 | Cite as

Long-term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection

  • Hiva Saffar
  • Ali-Reza Khalilian
  • Mohammed-Jafar Saffar
  • Abolghasem Ajami
Open Access
Research Paper



To determine the duration of protection conferred by the hepatitis B (HB) vaccination and the necessity of a booster dose.


Immediately after the initial blood sampling, 252 youths (aged 18.8-20.5 years, 52% females) with a history of neonatal HB vaccination with one dose of the HB vaccine received a booster. Serum concentrations of antibodies against the HB surface antigen were assessed in samples collected before and 10-14 days after the booster. Seroconversion from concentrations <10 to ≥10 IU/L were defined as a positive immune response.


Of the 252 participants, 131 were serosusceptible and 114 responded.


Nearly 90% of young people preserved their long-term protection; the results of this study do not support the use of an HB booster vaccination.


Booster vaccination HBV vaccine Immune memory Long-term protection 


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Copyright information

© Indian Academy of Pediatrics 2018

Authors and Affiliations

  • Hiva Saffar
    • 1
  • Ali-Reza Khalilian
    • 2
  • Mohammed-Jafar Saffar
    • 3
  • Abolghasem Ajami
    • 4
  1. 1.Department of Pathology, Shariati HospitalTehran University of Medical SciencesTehranIran
  2. 2.Department of BiostatisticsMazandaran University of Medical SciencesSariIran
  3. 3.Pediatric Infectious Diseases Ward and Antimicrobial Resistance Nosocomial Infection Research CenterMazandaran University of Medical SciencesSariIran
  4. 4.Immunology and Molecular and Cellular Biology Research CenterMazandaran University of Medical SciencesSariIran

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