Long-term Protection Against the Hepatitis B Virus Detected Through an Early Response to a Booster Dose Injection
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To determine the duration of protection conferred by the hepatitis B (HB) vaccination and the necessity of a booster dose.
Immediately after the initial blood sampling, 252 youths (aged 18.8-20.5 years, 52% females) with a history of neonatal HB vaccination with one dose of the HB vaccine received a booster. Serum concentrations of antibodies against the HB surface antigen were assessed in samples collected before and 10-14 days after the booster. Seroconversion from concentrations <10 to ≥10 IU/L were defined as a positive immune response.
Of the 252 participants, 131 were serosusceptible and 114 responded.
Nearly 90% of young people preserved their long-term protection; the results of this study do not support the use of an HB booster vaccination.
KeywordsBooster vaccination HBV vaccine Immune memory Long-term protection
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