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Indian Pediatrics

, Volume 55, Issue 1, pp 31–34 | Cite as

Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia

  • Manish Narang
  • Ravikumar Natarajan
  • Dheeraj Shah
  • Amarender Singh Puri
  • Vikas Manchanda
  • Mrinalini Kotru
Open Access
Research Paper

Abstract

Objective

To evaluate the proportion of children with moderate to severe iron-deficiency anemia who have associated celiac disease.

Methods

This cross-sectional analytical study was conducted among children aged 1 to 12 years of age with moderate-to-severe iron deficiency anemia and control children without anemia.Serum IgA-tissue trans-glutaminase levels were assessed in both cases and controls. All children with positive celiac serology underwent upper gastrointestinal endoscopy and duodenal biopsy; biopsy finding of Marsh grade 3 was considered positive for celiac disease.

Results

There were 152 anemic children and 152 controls with mean (SD) hemoglobinof 7.7 (1.8) and 12.2 (0.74) g/dL, respectively. 16 (10.5%) cases and 3 (2%) control patients had positive serology for celiac disease [OR (95% CI) 5.33 (1.52-18.67), P=0.007]. Six (3.9%) children with iron-deficiency anemia and none of the controls had biopsy features diagnostic of celiac disease.

Conclusion

In the Northern Indian tertiary-care hospital outpatient setting, Celiac disease was associated with 4% of children presenting with moderate-to-severe anemia.

Keywords

Biopsy Diagnosis Endoscopy Transglutaminases 

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Copyright information

© Indian Academy of Pediatrics 2018

Authors and Affiliations

  • Manish Narang
    • 1
  • Ravikumar Natarajan
    • 1
  • Dheeraj Shah
    • 1
  • Amarender Singh Puri
    • 2
  • Vikas Manchanda
    • 3
  • Mrinalini Kotru
    • 4
  1. 1.Division of Pediatric Gastroenterology, Department of PediatricsUniversity College of Medical Sciences and GTB HospitalDelhiIndia
  2. 2.Department of GastroenterologyGB Pant Institute of Post Graduate Medical Education and ResearchDelhiIndia
  3. 3.Department of Clinical Microbiology and Infectious DiseasesChacha Nehru Bal ChikitsalayaDelhiIndia
  4. 4.Department of PathologyUniversity College of Medical Sciences and GTB HospitalDelhiIndia

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