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Double dose versus standard dose hepatitis B vaccine in HIV-infected children: A randomized controlled trial

Indian Pediatrics volume 54, pages 1017–1020 (2017)Cite this article

Abstract

Objective

To compare the efficacy of double dose (20 μg) with standard dose (10 μg) of hepatitis B vaccine in HIV-infected children.

Methods

Unvaccinated HIV-infected children were randomized to receive 3 doses of double dose (N=27) or standard dose (N=28) of recombinant Hepatitis B vaccine. Anti-HBs antibody titres were measured 3 mo after the last dose. An antibody titre ≥10 mIU/mL 12 weaks after the third dose was considered as serporotection.

Result

Seroprotection was achieved by 17 (60.7%) children in standard dose group against 20 (74%) in the double dose group [RR (95%CI) 0.8 (0.17-1.7); P=0.29]. CD4 count < 500 cells/mm3 was significantly associated with lower rates of seroprotection.

Conclusion

Double dose of hepatitis B vaccine does not seem to provide any advantage when compared to standard dose in HIV-infected children.

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Affiliations

  1. Department of Pediatrics, MLN Medical College, Allahabad, Uttar Pradesh, India

    Shahid Akhtar Siddiqui, Manisha Maurya, Dk Singh, Anubha Srivastava & Ruchi Rai

Authors
  1. Shahid Akhtar Siddiqui
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  2. Manisha Maurya
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  3. Dk Singh
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  4. Anubha Srivastava
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  5. Ruchi Rai
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Corresponding author

Correspondence to Ruchi Rai.

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Siddiqui, S.A., Maurya, M., Singh, D. et al. Double dose versus standard dose hepatitis B vaccine in HIV-infected children: A randomized controlled trial. Indian Pediatr 54, 1017–1020 (2017). https://doi.org/10.1007/s13312-017-1203-2

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  • DOI: https://doi.org/10.1007/s13312-017-1203-2

Keywords

  • Immunization
  • Immunodeficiency
  • Prevention
  • Vaccination