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Long-term outcome of inflammatory bowel disease—Unclassified in children

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Abstract

Objectives

To document the frequency at diagnosis and evolution over time of inflammatory bowel disease-unclassified in children.

Methods

Analysis of case records (2004–2011) of patients diagnosed with inflammatory bowel disease-unclassified following uppergastrointestinal endoscopy, ileocolonoscopy and small bowel imaging. Any subsequent diagnostic reclassification by 2016 was recorded.

Results

344 children diagnosed as inflammatory bowel disease: 58% Crohn’s disease, 34.5% ulcerative colitis, and 7.5% (n=26) inflammatory bowel disease-unclassified. 25/26 inflammatory bowel disease-unclassified patients were followed for 4.5–11.5 years. 17 of these patients needed endoscopic reevaluation leading to changed diagnosis in ten (Crohn’s disease 7, ulcerative colitis 3).

Conclusion

7.5% (25/344) of inflammatory bowel disease children had inflammatory bowel disease-unclassified at diagnosis; 10 (40%) evolved into Crohn’s disease or ulcerative colitis.

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References

  1. Levine A, Koletzko S, Turner D, Escher JC, Cucchiara S, de Ridder L, et al. ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents. J Pediatr Gastroenterol Nutr. 2014;58:795–806.

    CAS  PubMed  Google Scholar 

  2. IBD Working Group of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Inflammatory bowel disease in children and adolescents: recommendations for diagnosis–the Porto criteria. J Pediatr Gastroenterol Nutr. 2005;41:1–7.

    Google Scholar 

  3. Sandhu BK, Fell JM, Beattie RM, Mitton SG, Wilson DC, Jenkins H; IBD Working Group of the British Society of Paediatric Gastroenterology, Hepatology, and Nutrition. Guidelines for the Management of Inflammatory Bowel Disease in Children in the United Kingdom. J Pediatr Gastroenterol Nutr. 2010;50:S1–13.

    Article  PubMed  Google Scholar 

  4. Prenzel F, Uhlig HH. Frequency of indeterminate colitis in children and adults with IBD- a metaanalysis. J Crohns Colitis. 2009;3:277–81.

    Article  PubMed  Google Scholar 

  5. Turunen P, Kolho KL, Auvinen A, Iltanen S, Huhtala H, Ashorn M. Incidence of inflammatory bowel disease in Finnish children, 1987–2003. Inflamm Bowel Dis. 2006;12:677–83.

    Article  Google Scholar 

  6. Winter DA, Karolewska-Bochenek K, Lazowska-Przeorek I, Lionetti P, Mearin ML, Chong SK, et al. Pediatric IBDunclassified is less common than previously reported; Results of an 8-year audit of the EUROKIDS Registry. Inflamm Bowel Dis. 2015;21:2145–53.

    Article  PubMed  Google Scholar 

  7. Malaty HM, Mehta S, Abraham B, Garnett EA, Ferry GD. The natural course of inflammatory bowel diseaseindeterminate from childhood to adulthood: within a 25 year period. Clin Exp Gastroenterol. 2013; 23:115–21.

    Article  Google Scholar 

  8. Newby EA, Croft NM, Green M, Hassan K, Heuschkel RB, Jenkins H, et al. Natural history of paediatric inflammatory bowel diseases over a 5-year follow-up: A retrospective review of data from the register of paediatric inflammatory bowel diseases. J Pediatr Gastroenterol Nutr. 2008;46: 539–45.

    Article  PubMed  Google Scholar 

  9. Aloi M, Birimberg-Schwartz L, Buderus S, Hojsak I, Fell JM, Bronsky J, et al. Treatment options and outcomes of pediatric IBDU compared with other IBD subtypes: A retrospective multicenter study from the IBD Porto Group of ESPGHAN. Inflamm Bowel Dis. 2016;22:1378–83.

    Article  PubMed  Google Scholar 

  10. Birimberg-Schwartz L, Zacker DM, Akriv A, Cucchiara S, Cameron FL, Wilson DC, et al. Development and validation of diagnostic criteria for IBD subtypes with an emphasis on IBD-Unclassified in children: A multicenter study from the Pediatric IBD Porto group of ESPGHAN. J Crohns Colitis. 2017 Apr 18 [Epub ahead of print].

    Google Scholar 

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Correspondence to Siba Prosad Paul.

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Paul, S.P., Sandhu, B.K. Long-term outcome of inflammatory bowel disease—Unclassified in children. Indian Pediatr 54, 742–745 (2017). https://doi.org/10.1007/s13312-017-1166-3

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  • DOI: https://doi.org/10.1007/s13312-017-1166-3

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