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Impact of antibiotic policy on antibiotic consumption in a neonatal intensive care unit in India

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Abstract

Objective

To study the impact of initiating antibiotic policy on antibiotic consumption in a neonatal intensive care unit (NICU).

Methods

This retrospective study was conducted between January, 2013 and December, 2014 in a 30 bed NICU. The antibiotic policy for neonatal sepsis was initiated on January 1st, 2014. The overall antibiotic consumption (Daily Defined Dose [DDD] per 100 patient-days), one year before and one year after the initiation of antibiotic policy was evaluated using interrupted time-series analysis.

Results

There was no significant change (12.47 vs. 11.47 DDD/100 patient-days; P = 0.57) in overall antibiotic consumption. A significant increase in the proportion of patients on first-line agents (ampicillin and gentamicin) (66% (n=449) vs. 84% (n=491); P <0.001) and significant decrease in consumption of third generation cephalosporins (1.45 vs. 0.45 DDD/100 patient-days; P =0.002) was observed.

Conclusion

Antibiotic policy increased the use of first-line agents and decreased the consumption of third generation cephalosporins.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Rural Development Trust Children’s Hospital, Bathalapalli, Andhra Pradesh, India

    Dasaratha Ramaiah Jinka

  2. Department of Infectious Diseases, Rural Development Trust Children’s Hospital, Bathalapalli, Andhra Pradesh, India

    Gerardo Alvarez-Uria

  3. Department of Clinical Microbiology, Rural Development Trust Children’s Hospital, Bathalapalli, Andhra Pradesh, India

    RaghuPrakash Reddy Nayakanti

  4. Center for Disease Dynamics, Economics & Policy, New Delhi, India

    Sumanth Gandra

  5. Department of Pediatrics, Rural Development Trust Hospital, Kanekal, AP, India

    Durgesh Tadepalli

  6. Department of Neonatology, SJD Hospital, Barcelona, Spain

    Nuria Torre

Authors
  1. Dasaratha Ramaiah Jinka
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  2. Sumanth Gandra
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  3. Gerardo Alvarez-Uria
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  4. Nuria Torre
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  5. Durgesh Tadepalli
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  6. RaghuPrakash Reddy Nayakanti
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Corresponding author

Correspondence to Dasaratha Ramaiah Jinka.

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Jinka, D.R., Gandra, S., Alvarez-Uria, G. et al. Impact of antibiotic policy on antibiotic consumption in a neonatal intensive care unit in India. Indian Pediatr 54, 739–741 (2017). https://doi.org/10.1007/s13312-017-1165-4

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  • DOI: https://doi.org/10.1007/s13312-017-1165-4

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