Skip to main content
SpringerLink
Log in

Fluid supplementation versus no fluid supplementation in late preterm and term neonates with asymptomatic polycythemia: A randomized controlled trial

  • Research Paper
  • Published:
Indian Pediatrics Aims and scope Submit manuscript

Abstract

Objective

To compare supplemental intravenous fluids with no supplementation in asymptomatic polycythemic late preterm and term neonates.

Methods

55 infants with venous haematocrit of 65-75 were randomly allocated to receive either 25 mL/kg IV normal saline over 6-8 hours or routine fluids. They were followed up for 48 hours.

Results

There was no significant difference between fluid supplementation and control groups regarding need for partial exchange transfusion [6/27 (22.2%) vs 8/28 (28.6%); P=0.59].

Conclusions

We did not find any evidence of clinical benefit with IV fluid supplementation in late preterm and term neonates with asymptomatic polycythemia (PCV 65-75).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Watchko JF. Common hematologic problems in the newborn nursery. Pediatr Clin North Am. 2015;62:509–24.

    Article  PubMed  Google Scholar 

  2. Celik IH, Demirel G, Canpolat FE, Dilmen U. A common problem for neonatal intensive care units: Late preterm infants, a prospective study with term controls in a large perinatal center. J Matern-Fetal Neonatal Med. 2013;26:459–62.

    Article  PubMed  Google Scholar 

  3. Pappas A, Delaney-Black V. Differential diagnosis and management of polycythemia. Pediatr Clin North Am. 2004;51:1063–86.

    Article  PubMed  Google Scholar 

  4. Mimouni FB, Merlob P, Dollberg S, Mandel D. Neonatal polycythaemia: critical review and a consensus statement of the Israeli Neonatology Association. Acta Paediatr Oslo Nor. 1992. 2011;100:1290–6.

    Google Scholar 

  5. Schimmel MS, Bromiker R, Soll RF. Neonatal polycythemia: Is partial exchange transfusion justified? Clin Perinatol. 2004;31:545–53, ix–x.

    Article  PubMed  Google Scholar 

  6. Morag I, Strauss T, Lubin D, Schushan-Eisen I, Kenet G, Kuint J. Restrictive management of neonatal polycythemia. Am J Perinatol. 2011;28:677–82.

    Article  PubMed  Google Scholar 

  7. Sankar MJ, Agarwal R, Deorari A, Paul VK. Management of polycythemia in neonates. Indian J Pediatr. 2010;77:1117–21.

    Article  PubMed  Google Scholar 

  8. Ozek E, Soll R, Schimmel MS. Partial exchange transfusion to prevent neurodevelopmental disability in infants with polycythemia. Cochrane Database Syst Rev. 2010;1:CD005089.

    Google Scholar 

  9. Shohat M, Reisner SH, Mimouni F, Merlob P. Neonatal polycythemia: II. Definition related to time of sampling. Pediatrics. 1984;73:11–3.

    CAS  PubMed  Google Scholar 

  10. Weippl G. [The practical value of venous-capillary haemocrit difference in new borns (author’s transl)]. Padiatr Padol. 1974;9:28–30.

    CAS  PubMed  Google Scholar 

  11. Villalta IA, Pramanik AK, Diaz-Blanco J, Herbst JJ. Diagnostic errors in neonatal polycythemia based on method of hematocrit determination. J Pediatr. 1989;115:460–2.

    Article  CAS  PubMed  Google Scholar 

  12. Kumar A, Ramji S. Effect of partial exchange transfusion in asymptomatic polycythemic LBW babies. Indian Pediatr. 2004;41:366–72.

    PubMed  Google Scholar 

  13. Falk JL, Rackow EC, Weil MH. Colloid and crystalloid fluid resuscitation. Acute Care. 1983;10:59–94.

    PubMed  Google Scholar 

  14. Rawlings JS, Pettett G, Wiswell TE, Clapper J. Estimated blood volumes in polycythemic neonates as a function of birth weight. J Pediatr. 1982;101:594–9.

    Article  CAS  PubMed  Google Scholar 

  15. Goldberg K, Wirth FH, Hathaway WE, Guggenheim MA, Murphy JR, Braithwaite WR, et al. Neonatal hyperviscosity. II. Effect of partial plasma exchange transfusion. Pediatrics. 1982;69:419–25.

    CAS  PubMed  Google Scholar 

  16. Thornton CJ, Shannon DL, Hunter MA, Ramamurthy RS, Brans YW. Body water estimates in neonatal polycythemia. J Pediatr. 1983;102:113–7.

    Article  CAS  PubMed  Google Scholar 

  17. Brans YW, Shannon DL, Ramamurthy RS. Neonatal polycythemia: II. Plasma, blood and red cell volume estimates in relation to hematocrit levels and quality of intrauterine growth. Pediatrics. 1981;68:175–82.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Neonatology, Departments of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India

    Mangalabharathi Sundaram, Sourabh Dutta & Anil Narang

Authors
  1. Mangalabharathi Sundaram
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sourabh Dutta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Anil Narang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mangalabharathi Sundaram.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sundaram, M., Dutta, S. & Narang, A. Fluid supplementation versus no fluid supplementation in late preterm and term neonates with asymptomatic polycythemia: A randomized controlled trial . Indian Pediatr 53, 983–986 (2016). https://doi.org/10.1007/s13312-016-0972-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-016-0972-3

Keywords

Search

Navigation