Skip to main content

Advertisement

SpringerLink
Log in

Is it right time to introduce mumps vaccine in India’s Universal immunization program?

  • Perspective
  • Published:
Indian Pediatrics Aims and scope Submit manuscript

Abstract

Measles, mumps and rubella are vaccine preventable diseases. However, morbidity and mortality due to these diseases remain largely unnoticed in India. Measles has received much attention; mumps and rubella still need to garner attention. According to the World Health Organization, near-elimination of mumps could be achieved by maintaining high vaccine coverage using a two-dose strategy. However, Government of India has not yet decided on mumps vaccine. In this review, we have reviewed sero-prevalence studies, vaccine studies, outbreak investigations, virus isolation and virus genotyping studies on mumps. Overall, mumps seems to be a significant public health problem in India, but does not garner attention due to the absence of a surveillance and documentation system. Thus, inclusion of mumps antigen in the Universal immunization program would have added advantages, the economic burden imposed by the cost of the vaccine offset by a reduction in disease burden.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hviid A, Rubin S, Mühlemann K. Mumps. Lancet. 2008;371:932–44.

    Article  PubMed  Google Scholar 

  2. Philip RN, Reinhard KR, Lackman DB. Observations on a mumps epidemic in a “virgin” population. 1958. Am J Epidemiol. 1995;142:233–53.

    CAS  PubMed  Google Scholar 

  3. Dayan GH, Rubin S. Mumps outbreaks in vaccinated populations: are available mumps vaccines effective enough to prevent outbreaks? Clin Infect Dis. 2008;47:1458–67.

    Article  PubMed  Google Scholar 

  4. Vashishtha VM, Yewale VN, Bansal CP, Mehta PJ. IAP perspectives on measles and rubella elimination strategies. Indian Pediatr. 2014;51:719–22.

    Article  PubMed  Google Scholar 

  5. Vashishtha VM, Yadav S, Dabas A, Bansal CP, Agarwal RC, Yewale VN, et al. IAP Position Paper on burden of mumps in India and vaccination strategies. Indian Pediatr. 2015;52:505–14.

    Article  PubMed  Google Scholar 

  6. John TJ. An outbreak of mumps in Thiruvananthapuram district. Indian Pediatr. 2004;41:298–300.

    PubMed  Google Scholar 

  7. Geeta MG, Kumar PK. Mumps—need for urgent action. Indian Pediatr. 2004;41:1181–2.

    CAS  PubMed  Google Scholar 

  8. Ghatage ST, Kakade GM. An outbreak of mumps meningoencephalitis in Sangli district. Indian Pediatr. 2007;44:235.

    CAS  PubMed  Google Scholar 

  9. Vaidya SR, Chowdhury DT, Kumbhar NS, Tomar R, Kamble MB, Kazi MI. Circulation of two mumps virus genotypes in an unimmunized population in India. J Med Virol. 2013;85:1426–32.

    Article  CAS  PubMed  Google Scholar 

  10. Vandana KE, Arunkumar G, Bairy I. Role of laboratory in rapid diagnosis of atypical mumps. Braz J Infect Dis. 2010;14:201–2.

    Article  CAS  PubMed  Google Scholar 

  11. Raut CG, Sinha DP, Jayaprakash H, Hanumiah H, Manjunatha MJ. Mumps disease outbreak in Davangere district of Karnataka, India. Indian J Med Microbiol. 2015;33:378–82.

    Article  CAS  PubMed  Google Scholar 

  12. Mishra B, Pujhari SK, Dhiman V, Mahalakshmi P, Bharadwaj A, Pokhrel S, et al. Genotyping and subtyping of mumps virus isolates from the Indian subcontinent. Arch Virol. 2013;158:2359–63.

    Article  CAS  PubMed  Google Scholar 

  13. Bhatnagar N, Kaur R, Gupta M, Sharma D. Introducing combined measles, mumps and rubella vaccine in Chandigarh, India: Issues and concerns. Indian Pediatr. 2014;51:441–3.

    Article  PubMed  Google Scholar 

  14. Samuel CJ, Thomas AM, Bhatia D. Mumps outbreak in dental care providers in a North Indian dental college. CHRISMED J Health Res. 2014;1:216–7. Available from: http://www.cjhr.org/text.asp?2014/1/3/216/ Accessed June 8, 2015.

    Article  Google Scholar 

  15. Malayan J, Warrier A, Ramanan PV, Reddy SN, Manickan E. Unnoticeable mumps infection in India: Does MMR vaccine protect against circulating mumps virus genotype C? World Academy of Science, Engineering & Technology 2012;6:1365–71.

    Google Scholar 

  16. Jeevan M, Sambantham S, Thangam M. Characterisation of mumps virus genotype C among patients with mumps in India. Indian J Med Microbiol. 2013;31:290–2.

    Article  CAS  PubMed  Google Scholar 

  17. Carey DE, Myers RM, Webb JK. Search for herpes simplex, mumps and lymphocytic choriomeningitis associated with central nervous system disease at Vellore, Southern India. Indian J Med Res. 1969;57:567–8.

    CAS  PubMed  Google Scholar 

  18. Beig FK, Malik A, Rizvi M, Acharya D, Khare S. Etiology and clinico-epidemiological profile of acute viral encephalitis in children of western Uttar Pradesh, India. Int J Infect Dis. 2010;14:e141–6.

    Article  PubMed  Google Scholar 

  19. Saha I, Haldar D, Paul B, Shrivastava P, Das DK, Pal M, et al. An epidemiological investigation of mumps outbreak in a slum of Kolkata. J Commun Dis. 2012;44:29–36.

    PubMed  Google Scholar 

  20. Infectious Disease Surveillance (IDsurv) by Indian Academy of Pediatrics. Available from: http://www.idsurv.org. Accessed June 08, 2015.

  21. World Health Organization. Mumps virus nomenclature update: 2012. Wkly Epidemiol Rec Wkly Epidemiol Rec. 2012;87:217–24.

    Google Scholar 

  22. Waller SO, Rai J, Bannerjee AK. A serological survey of mumps. Indian J Med Res. 1965;53:819–21.

    CAS  PubMed  Google Scholar 

  23. Chakravarti A, Yadav S, Berry N, Rastogi A, Mathur MD. Evaluation of serological status of rubella and mumps in children below five years. Indian J Med Res. 1999;110:1–3.

    CAS  PubMed  Google Scholar 

  24. Arunkumar G, Vandana KE, Sathiakumar N. Prevalence of measles, mumps, rubella, and varicella susceptibility among health science students in a University in India. Am J Ind Med. 2013;56:58–64.

    Article  CAS  PubMed  Google Scholar 

  25. Singh R, John TJ, Cherian T, Raghupathy P. Immune response to measles, mumps and rubella vaccine at 9, 12 & 15 months of age. Indian J Med Res. 1994;100:155–9.

    CAS  PubMed  Google Scholar 

  26. Bhargava I, Chhaparwal BC, Phadke MA, Irani SF, Chhaparwal D, Dhorje S, et al. Immunogenicity and reactogenicity of indigenously produced MMR vaccine. Indian Pediatr. 1995;32:983–8.

    CAS  PubMed  Google Scholar 

  27. Yadav S, Thukral R, Chakarvarti A. Comparative evaluation of measles, mumps and rubella vaccine at 9 & 15 months of age. Indian J Med Res. 2003;118:183–6.

    PubMed  Google Scholar 

  28. Raut SK, Kulkarni PS, Phadke MA, Jadhav SS, Kapre SV, Dhere RM, et al. Persistence of antibodies induced by measles-mumps-rubella vaccine in children in India. Clin Vaccine Immunol. 2007;14:1370–1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Gomber S, Arora SK, Das S, Ramachandran VG. Immune response to second dose of MMR vaccine in Indian children. Indian J Med Res. 2011;134:302–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  30. Malaiyan J, Menon T. Low vaccine efficacy of mumps component among MMR vaccine recipients in Chennai, India. Indian J Med Res. 2014a;139:773–5.

    PubMed  PubMed Central  Google Scholar 

  31. Malaiyan J, Duraipandian T, Warrier A, Menon T. Low rate of seropositivity (IgG) to mumps component in MMR vaccinees in Chennai, South India. Indian J Med Res. 2014;139:949–51.

    PubMed  PubMed Central  Google Scholar 

  32. Vaidya SR, Brown DW, Jin L, Samuel D, Andrews N, Brown KE. Development of a focus reduction neutralization test (FRNT) for detection of mumps virus neutralizing antibodies. J Virol Methods. 2010;163:153–6.

    Article  CAS  PubMed  Google Scholar 

  33. Vaidya SR, Kumbhar NS, Bhide VS. Detection of measles, mumps and rubella viruses by immunocolorimetric assay and its application in focus reduction neutralization tests. Microbiol Immunol. 2014;58:666–74.

    Article  CAS  PubMed  Google Scholar 

  34. Vaidya SR, Dvivedi GM, Jadhav SM. Crossneutralization between three mumps viruses and mapping of hemagglutinin-neuraminidase (HN) epitopes. Indian J Med Res. 2016;143:37–42.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. WHO Accredited National Reference Laboratory for Measles and Rubella, National Institute of Virology, 20-A, Dr Ambedkar Road, Post Box 11, Pune, 411 001, India

    Sunil R. Vaidya & V. S. Hamde

Authors
  1. Sunil R. Vaidya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. S. Hamde
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. S. Hamde.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Vaidya, S.R., Hamde, V.S. Is it right time to introduce mumps vaccine in India’s Universal immunization program?. Indian Pediatr 53, 469–473 (2016). https://doi.org/10.1007/s13312-016-0874-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-016-0874-4

Keywords

Search

Navigation