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Hospital-based surveillance of invasive pneumococcal disease and pneumonia in South Bangalore, India

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Abstract

Objective

To estimate the incidence of invasive pneumococcal disease and pneumonia, distribution of pneumococcal serotypes, and antibiotic susceptibility in children aged 28 days to <60 months.

Design

Hospital-based surveillance.

Setting

South Bangalore, India.

Participants

9950 children aged 28 days to <60 months with clinical suspicion of invasive pneumococcal disease or pneumonia.

Results

The estimated at-risk population included 224,966 children <5 years of age. Forty cases of invasive pneumococcal disease were identified. Estimated invasive pneumococcal disease incidence was 17.8/100,000 with incidence being highest among children aged 6 months to <12 months (49.9/100,000). Clinical pneumonia syndrome was the most frequent diagnosis (12.5/100,000). Pneumococcal serotypes included: 6A (n=6, 16.7%); 14 (n=5, 13.9%); 5 (n=4, 11.1%); 6B (n=4, 11.1%); 1, 18C, and 19A (n=3 each, 8.3%); 9V (n=2, 5.6%); and 3, 4, 10C, 18A, 18F, and 19F (n=1 each, 2.8%). Serotypes 6A, 14, 6B, 1, 18C, 19A, 9V, 4, 10C, and 18A showed antibiotic resistance. Clinical pneumonia incidence was 2109/100,000, with incidence being highest among children aged 28 days to <6 months (5033/100,000). Chest radiograph-confirmed pneumonia incidence was 1114/100,000, with incidence being highest among children aged 28 days to <6 months (2413/100,000).

Conclusion

Invasive pneumococcal disease and pneumonia were found to be common causes of morbidity in young children living in South Bangalore, India.

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Authors and Affiliations

  1. Kempegowda Institute of Medical Sciences,., 121/13, T. Mariyappa Road, 1st Block, Jayanagara, Bangalore, 560011, India

    Ramalingowda Nisarga

  2. Vani Vilas Hospital, Bangalore Medical College & Research Institute, Bangalore, India

    R. Premalatha

  3. Indira Gandhi Institute of Child Health, Bangalore, India

    Shivananda, K. L. Ravikumar, U. Shivappa, A. Gopi & S. B. Chikkadasarahalli

  4. International Vaccine Institute, Seoul, Korea

    R. Batuwanthudawe & S. A. Kim

  5. Wayne State University, Detroit, MI, USA

    P. E. Kilgore

  6. Pfizer Inc, Paris, France

    I. Balter & S. Jouve

  7. Pfizer Inc, Collegeville, PA, USA

    J. Ye & M. Moscariello

Authors
  1. Ramalingowda Nisarga
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  2. R. Premalatha
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  3. Shivananda
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  4. K. L. Ravikumar
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  5. U. Shivappa
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  6. A. Gopi
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  7. S. B. Chikkadasarahalli
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  8. R. Batuwanthudawe
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  9. P. E. Kilgore
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  10. S. A. Kim
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  11. I. Balter
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  12. S. Jouve
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  13. J. Ye
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  14. M. Moscariello
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Corresponding author

Correspondence to Ramalingowda Nisarga.

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Nisarga, R., Premalatha, R., Shivananda et al. Hospital-based surveillance of invasive pneumococcal disease and pneumonia in South Bangalore, India. Indian Pediatr 52, 205–211 (2015). https://doi.org/10.1007/s13312-015-0607-0

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  • DOI: https://doi.org/10.1007/s13312-015-0607-0

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