Skip to main content

Risk factors associated with Methicillin-resistant Staphylococcus aureus infection in children

Indian Pediatrics volume 52, pages 31–33 (2015)Cite this article

Abstract

Objective

To identify the clinical variables that differentiate MRSA (Methicillin-resistant Staphylococcus aureus) from MSSA (Methicillin-sensitive S. aureus) infection.

Methods

Cases having culture isolates of Staphylococcus species were recruited. Baseline and other laboratory parameters were compared between MSSA and MRSA sub-groups to identify the predictors for MRSA.

Results

Out of 98 isolates of S.aureus, 46 (47%) were MRSA. Significant leukocytosis was found in cases with MRSA (P <0.03). None of the other clinical variables could differentiate MRSA from MSSA infection.

Conclusion

Presence of leukocytosis was twice more likely to predict MRSA than MSSA at admission. Empiric therapy must be guided by antimicrobial sensitivity pattern of regional culture isolates.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. Cosgrove SE, Fowler VG Jr. Management of methicillinresistant Staphylococcus aureus bacteremia. Clin Infect Dis. 2008;46:S386–93.

    Article  Google Scholar 

  2. Boucher HW, Corey GR. Epidemiology of methicillinresistant Staphylococcus aureus. Clin Infect Dis. 2008;46:S344–9.

    Article  Google Scholar 

  3. Stryjewski ME, Chambers HF. Skin and soft-tissue infections caused by community-acquired methicillinresistant Staphylococcus aureus. Clin Infect Dis. 2008;46:S368–77.

    Article  Google Scholar 

  4. Clinical and Laboratory Standards Institute. 2013. Performance standards for Antimicrobial susceptibility testing; twenty third Informational supplement. M100-S23. Accessed September 24, 2014.

    Google Scholar 

  5. Centers for Disease Control and Prevention. 2011. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Methicillin-Resistant Staphylococcus aureus, 2011. Available from: http://www.cdc.gov/abcs/reportsfindings/survreports/mrsa11. Accessed September 23, 2014.

    Google Scholar 

  6. Lerner Norma B. The anaemia. In: Kliegman RM, Stanton BF, St.Geme JW, Schor NF, Behrman RE. Nelson Textbook of Pediatrics. 19th ed. Philadelphia,: Elsevier; 2011.p.1648.

    Chapter  Google Scholar 

  7. Goldstein B, Giroir B, Randolph A, International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6:2–8.

    Article  PubMed  Google Scholar 

  8. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39:165–228.

    Article  CAS  PubMed  Google Scholar 

  9. Joshi S, Ray P, Manchanda V, Bajaj J, Chitinis DS, Gautam V, et al. Methicillin resistant Staphylococcus aureus (MRSA) in India: Prevalence and susceptibility pattern. Indian J Med Res. 2013;137:363–9.

    PubMed Central  Google Scholar 

  10. Golding GR, Levett PN, McDonald RR, Irvine J, Nsungu M, Woods S, et al. A comparison of risk factors associated with community-associated methicillin-resistant and- susceptible Staphylococcus aureus infections in remote communities. Epidemiol Infect. 2010;138:730–7.

    Article  CAS  PubMed  Google Scholar 

  11. Miller LG, Perdreau-Remington F, Bayer AS, Diep B, Tan N, Bharadwa K, et al. Clinical and epidemiologic characteristics cannot distinguish community-associated methicillin-resistant Staphylococcus aureus infection from methicillin-susceptible S. aureus infection: a prospective investigation. Clin Infect Dis. 2007;44:471–82.

    Article  CAS  PubMed  Google Scholar 

  12. Kini AR, Shetty V, Kumar AM, Shetty SM, Shetty A. Community-associated, methicillin-susceptible, and methicillin-resistant Staphylococcus aureus bone and joint infections in children: experience from India. J Pediatr Orthop Part B. 2013;22:158–66.

    Article  Google Scholar 

  13. Ju KL, Zurakowski D, Kocher MS. Differentiating between methicillin-resistant and methicillin-sensitive Staphylococcus aureus osteomyelitis in children: an evidence-based clinical prediction algorithm. J Bone Joint Surg Am. 2011;93:1693–701.

    Article  PubMed  Google Scholar 

Download references

Author information

Affiliations

  1. Departments of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), 605006, Pondicherry, India

    Kandasamy Senthilkumar & Niranjan Biswal

  2. Departments of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India

    Sujatha Sistla

Authors
  1. Kandasamy Senthilkumar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Niranjan Biswal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sujatha Sistla
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Niranjan Biswal.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Senthilkumar, K., Biswal, N. & Sistla, S. Risk factors associated with Methicillin-resistant Staphylococcus aureus infection in children. Indian Pediatr 52, 31–33 (2015). https://doi.org/10.1007/s13312-015-0562-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-015-0562-9

Keywords

  • MRSA
  • Risk factors