Skip to main content
Log in

Thyroid dysfunction in Indian children with down syndrome

  • Research Letters
  • Published:
Indian Pediatrics Aims and scope Submit manuscript

Abstract

This record review of 82 children with Down Syndrome (DS) between April 2004 and March 2014 who had thyroid dysfunction, showed that majority (76, 92.6%) had subclinical hypothyroidism. Of the 60 patients who underwent radionuclide scan, 63.3% had a normal gland; the rest exhibited only impaired tracer uptake. Ultrasonograms done in 20 patients showed reduction of thyroid gland size in 3 (15%) patients only.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. King K, O’Gorman C, Gallagher S. Thyroid dysfunction in children with Down syndrome: a literature review. Ir J Med Sci. 2014;183:1–6.

    Article  PubMed  CAS  Google Scholar 

  2. Pueschel SM, Annerén G, Durlach R, Flores J, Sustrová M, Verma IC. Guidelines for optimal medical care of persons with Down syndrome. Acta Paediatr. 1995;84:823–7.

    Article  PubMed  CAS  Google Scholar 

  3. Bull MJ. Committee on Genetics. Health supervision for children with Down syndrome. Pediatrics. 2011;128:393–406.

    Google Scholar 

  4. The Association of Clinical Biochemistry, 2006. UK Guidelines for the Use of Thyroid Function Tests. Available from: http://www.british-thyroid-association.org. Accessed on 01 July, 2014.

  5. Güven A, Yildizn. Profile of hypothyroidism in Down’s Syndrome. J Clin Res Pediatr Endocrinol. 2013;5:116–20.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Predieri B, Garavelli L, Bonetti A, Vellani G, Predieri F, sCattelani C, et al. Ten-years longitudinal study of thyroid function in children with Down syndrome. Horm Res Paediatr. 2011;76:47.

    Article  Google Scholar 

  7. Karlsson B, Gustafsson J, Hedov G, Ivarsson SA, Annerén G. Thyroid dysfunction in Down’s syndrome: relation to age and thyroid autoimmunity. Arch Dis Child. 1998;79:242–5.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  8. van Trotsenburg AS, Vulsma T, van Rozenburg-Marres SL, van Baar AL, Ridder JC, Heymans HS, et al. The effect of thyroxine treatment started in the neonatal period on development and growth of two-year-old Down syndrome children: a randomized clinical trial. J Clin Endocrinol Metab. 2005;90:3304–11.

    Article  PubMed  Google Scholar 

  9. Kowalczyk K, Pukajlo K, Malczewska A, Król-Chwastek A, Barg E. L-thyroxine therapy and growth processes in children with Down syndrome. Adv Clin Exp Med. 2013;22:85–92.

    PubMed  Google Scholar 

  10. Gupta N, Kabra M. Diagnosis and management of Down syndrome. Indian J Pediatr. 2014;81:560–7.

    Article  Google Scholar 

  11. Schaffner J, Chochua S, Kourbatova EV, Barragan M, Wang YF, Blumberg HM, et al. High mortality among patients with positive blood cultures at a children’s hospital in Tbilisi, Georgia. J Infect Dev Ctries. 2009;3:267–72.

    PubMed  PubMed Central  Google Scholar 

  12. Kollef MH. Inadequate antimicrobial treatment: An important determinant of outcome for hospitalized patients. Clin Infect Dis. 2000;31:S131–8.

    Article  Google Scholar 

  13. Behrendt G, Schneider S, Brodt HR, Just-Nübling G, Shah PM. Influence of antimicrobial treatment on mortality in septicemia. J Chemother. 1999;11:179–86.

    Article  PubMed  CAS  Google Scholar 

  14. Bhattacharjee A, Sen MR, Prakash P, Gaur A, Anupurba S. Increased prevalence of extended spectrum beta lactamase producers in neonatal septicaemic cases at a tertiary referral hospital. Indian J Med Microbiol. 2008;26:356–60.

    Article  PubMed  CAS  Google Scholar 

  15. Malini A, Deepa EK, Gokul BN, Prasad SR. Nonfermenting gram-negative bacilli infections in a tertiary care hospital in Kolar, Karnataka. J Lab Physicians. 2009;1:62–6.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  16. Centers for Disease Control and Prevention. 2013. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2012.

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Devi Dayal or Winsley Rose.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dayal, D., Jain, P., Panigrahi, I. et al. Thyroid dysfunction in Indian children with down syndrome. Indian Pediatr 51, 751–753 (2014). https://doi.org/10.1007/s13312-014-0495-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13312-014-0495-8

Keywords

Navigation