Abstract
This record review of 82 children with Down Syndrome (DS) between April 2004 and March 2014 who had thyroid dysfunction, showed that majority (76, 92.6%) had subclinical hypothyroidism. Of the 60 patients who underwent radionuclide scan, 63.3% had a normal gland; the rest exhibited only impaired tracer uptake. Ultrasonograms done in 20 patients showed reduction of thyroid gland size in 3 (15%) patients only.
Similar content being viewed by others
References
King K, O’Gorman C, Gallagher S. Thyroid dysfunction in children with Down syndrome: a literature review. Ir J Med Sci. 2014;183:1–6.
Pueschel SM, Annerén G, Durlach R, Flores J, Sustrová M, Verma IC. Guidelines for optimal medical care of persons with Down syndrome. Acta Paediatr. 1995;84:823–7.
Bull MJ. Committee on Genetics. Health supervision for children with Down syndrome. Pediatrics. 2011;128:393–406.
The Association of Clinical Biochemistry, 2006. UK Guidelines for the Use of Thyroid Function Tests. Available from: http://www.british-thyroid-association.org. Accessed on 01 July, 2014.
Güven A, Yildizn. Profile of hypothyroidism in Down’s Syndrome. J Clin Res Pediatr Endocrinol. 2013;5:116–20.
Predieri B, Garavelli L, Bonetti A, Vellani G, Predieri F, sCattelani C, et al. Ten-years longitudinal study of thyroid function in children with Down syndrome. Horm Res Paediatr. 2011;76:47.
Karlsson B, Gustafsson J, Hedov G, Ivarsson SA, Annerén G. Thyroid dysfunction in Down’s syndrome: relation to age and thyroid autoimmunity. Arch Dis Child. 1998;79:242–5.
van Trotsenburg AS, Vulsma T, van Rozenburg-Marres SL, van Baar AL, Ridder JC, Heymans HS, et al. The effect of thyroxine treatment started in the neonatal period on development and growth of two-year-old Down syndrome children: a randomized clinical trial. J Clin Endocrinol Metab. 2005;90:3304–11.
Kowalczyk K, Pukajlo K, Malczewska A, Król-Chwastek A, Barg E. L-thyroxine therapy and growth processes in children with Down syndrome. Adv Clin Exp Med. 2013;22:85–92.
Gupta N, Kabra M. Diagnosis and management of Down syndrome. Indian J Pediatr. 2014;81:560–7.
Schaffner J, Chochua S, Kourbatova EV, Barragan M, Wang YF, Blumberg HM, et al. High mortality among patients with positive blood cultures at a children’s hospital in Tbilisi, Georgia. J Infect Dev Ctries. 2009;3:267–72.
Kollef MH. Inadequate antimicrobial treatment: An important determinant of outcome for hospitalized patients. Clin Infect Dis. 2000;31:S131–8.
Behrendt G, Schneider S, Brodt HR, Just-Nübling G, Shah PM. Influence of antimicrobial treatment on mortality in septicemia. J Chemother. 1999;11:179–86.
Bhattacharjee A, Sen MR, Prakash P, Gaur A, Anupurba S. Increased prevalence of extended spectrum beta lactamase producers in neonatal septicaemic cases at a tertiary referral hospital. Indian J Med Microbiol. 2008;26:356–60.
Malini A, Deepa EK, Gokul BN, Prasad SR. Nonfermenting gram-negative bacilli infections in a tertiary care hospital in Kolar, Karnataka. J Lab Physicians. 2009;1:62–6.
Centers for Disease Control and Prevention. 2013. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2012.
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Dayal, D., Jain, P., Panigrahi, I. et al. Thyroid dysfunction in Indian children with down syndrome. Indian Pediatr 51, 751–753 (2014). https://doi.org/10.1007/s13312-014-0495-8
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13312-014-0495-8