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Reverse vertical transmission of hepatitis-B from transfusion-infected children to biological mothers

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Abstract

Background

Perinatal and horizontal are the common modes of transmission of hepatitis-B virus in children.

Case characteristics

Two mother-child pairs with children having received multiple blood transfusions in past.

Observation

Both the mothers developed acute hepatitis-B infection whereas children were demonstrated to be having chronic infection with hepatitis-B.

Outcome

One mother cleared her hepatitis-B in fection whereas it persisted in the other. Both children required anti-viral treatment.

Message

Hepatitis-B virus may rarely get transmitted from infected children to their mothers causing acute infection.

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Author information

Authors and Affiliations

  1. Departments of Pediatric Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India

    Rajeev Khanna & Seema Alam

  2. Departments of Virology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi, India

    Ekta Gupta

  3. Department of Pediatrics, Dr. RPGMC, Tanda, Kangra (HP), India

    Sandesh Guleria, Jyoti Sharma & Sanjeev Chaudhary

  4. Departments of Pediatric Surgery, Pondicherry Institute of Medical Sciences, Pondicherry, 605 014, India

    Anjan Kumar Dhua & Manoj Joshi

  5. Departments of Pediatrics and Neonatology, Pondicherry Institute of Medical Sciences, Pondicherry, 605 014, India

    Nishad Plakkal & Lalitha Krishnan

  6. Department of Pediatrics, Government Medical College, Thiruvananthapuram, Kerala, India

    Priya Sreenivasan, Sobha Kumar & K. K. Santhosh Kumar

Authors
  1. Rajeev Khanna
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  2. Ekta Gupta
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  3. Seema Alam
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  4. Sandesh Guleria
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  5. Jyoti Sharma
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  6. Sanjeev Chaudhary
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  7. Anjan Kumar Dhua
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  8. Manoj Joshi
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  9. Nishad Plakkal
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  11. Priya Sreenivasan
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  13. K. K. Santhosh Kumar
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Corresponding authors

Correspondence to Rajeev Khanna, Anjan Kumar Dhua or Priya Sreenivasan.

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Khanna, R., Gupta, E., Alam, S. et al. Reverse vertical transmission of hepatitis-B from transfusion-infected children to biological mothers. Indian Pediatr 51, 739–746 (2014). https://doi.org/10.1007/s13312-014-0493-x

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  • DOI: https://doi.org/10.1007/s13312-014-0493-x

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