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Clinical and immunological profile of systemic lupus erythematosus

Indian Pediatrics volume 50, pages 405–407 (2013)Cite this article

Abstract

Pediatric onset systemic lupus erythematosus (SLE) is not uncommon and female to male ratio varies. Pediatric SLE patients have more severe disease at onset, higher rates of organ involvement and more aggressive clinical course than adults. We compared the clinical and immunological parameters among pediatric SLE and adult SLE from Western India. Twenty five children and 60 adult patients fulfilling American College of Rheumatology SLE criteria were included. Anti-nuclear antibodies, anti-dsDNA and complement (C3, C4) levels were tested. Of 25 pediatric SLE patients studied, 24% showed CNS involvement vs. 8.3% in adults SLE (P=0.0499). Lupus nephritis was seen in 75% adult patients vs. 52% among children. Hepatosplenomegaly was noted more among adult SLE 26.8% vs 12% among children. Alopecia was an exclusive features among adult SLE.

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Affiliations

  1. Department of Autoimmune Disorders, National Institute of Immunohematology, Indian Council of Medical Research, New Delhi, India

    Vandana Pradhan

  2. Department of Medicine, King Edward Memorial Hospital, Mumbai, India

    A. Rajadhyaksha

  3. Department of Autoimmune Disorders, National Institute of Immunohematology, Indian Council of Medical Research, 13th floor, KEM Hospital, Parel, Mumbai, 400 012, India

    Vandana Pradhan

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  1. Vandana Pradhan
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  2. M. Patwardhan
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  3. A. Rajadhyaksha
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  4. K. Ghosh
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Correspondence to Vandana Pradhan.

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Pradhan, V., Patwardhan, M., Rajadhyaksha, A. et al. Clinical and immunological profile of systemic lupus erythematosus. Indian Pediatr 50, 405–407 (2013). https://doi.org/10.1007/s13312-013-0115-z

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  • DOI: https://doi.org/10.1007/s13312-013-0115-z

Key words

  • Autoantibodies
  • Child
  • Lupus nephritis
  • India
  • Systemic lupus erythematosus