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Neurodevelopmental evaluation of very low birth weight infants with transient hypothyroxinemia at corrected age of 18–24 months

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Abstract

Objective

To perform neurodevelopmental evaluation at 18 to 24 months’ corrected age in very low birth infants (VLBW) with transient hypothyroxinemia.

Design

Cohort study.

Setting

Maternity teaching hospital.

Patients

Premature infants who were previously evaluated for thyroid hormone values in the first weeks of life were included.

Intervention

Data of these infants who weighed ≤1500 g and ≤32 weeks of gestation were retrieved for the current study. Available subjects (n=56) were evaluated for neurodevelopmental status at 18 to 24 months of corrected age. Bayley Scales of Infant Development -Second Edition (BSID-II) was performed to define Mental developmental index (MDI) and Psychomotor developmental index (PDI).

Results

The mean MDI and PDI scores were similar between the infants with and without transient hypothyroxinemia of prematurity (THOP) [79.9 ± 14.9 vs 70 ± 20.7, respectively (P=0.54); and 92.2 ± 16.4 vs 85.6 ± 18.9, respectively (P=0.68)]. After adjustment for gestational age and multiple prenatal, perinatal, and early and late neonatal variables, THOP was not associated with an increased risk of disabling cerebral palsy, or a reduction of MDI and PDI scores.

Conclusions

THOP may not be an important cause of problems in neurologic and mental development detected at the age of 18 to 24 months’ corrected age.

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Authors and Affiliations

  1. Department of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

    Dilek Dilli & Ugur Dilmen

  2. Department of Developmental Pediatrics, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey

    Zeynep Eras & Evrim Durgut Sakrucu

  3. Department of Pediatric Endocrinology, Keçiören Training and Research Hospital, Ankara, Turkey

    Nesibe Andiran

  4. Department of Neonatology, Zekai Tahir Burak Kadýn Saglýgi Egitim ve Arastirma Hastanesi Yenidogan Klinigi, Talatpasa bulvari, Hamamönü, Ankara, Turkey

    Dilek Dilli

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  1. Dilek Dilli
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  2. Zeynep Eras
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  3. Nesibe Andiran
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  4. Ugur Dilmen
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  5. Evrim Durgut Sakrucu
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Correspondence to Dilek Dilli.

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Dilli, D., Eras, Z., Andiran, N. et al. Neurodevelopmental evaluation of very low birth weight infants with transient hypothyroxinemia at corrected age of 18–24 months. Indian Pediatr 49, 711–715 (2012). https://doi.org/10.1007/s13312-012-0162-x

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  • DOI: https://doi.org/10.1007/s13312-012-0162-x

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