Clinical profile of drug resistant tuberculosis in children
This Cross-sectional observational study was conducted to determine the clinical profile of drug-resistant tuberculosis in children. Patients were classified as monoresistant TB, polyresistant TB, multidrug resistant (MDR)-TB and extensively drug resistant (XDR — TB). We coined a term called as Partial XDR-TB when isolates of Mycobacterium tuberculosis were confirmed to be resistant in vitro to be MDR along with either a fluoroquinolone or an aminoglycoside resistance (apart from streptomycin). Of 500 children analysed, 34 (6.8%) had drug resistant TB. Mean age of presentation was 6.8±3.2 years (Male: Female ratio 13:21). 18 (52.9%) children had been treated for tuberculosis in the past (1 defaulted), 7 patients had been in contact with an adult suffering from drug resistant TB and 3 patients (10.3%) were HIV co-infected. Fourteen children (41.2 %) had MDR TB, 11 (32.4 %) had Partial XDR, 1 each (2.9 %) had polyresistant TB and XDR TB. Clinical features of DR-TB are similar in all age groups. Past history of TB with treatment with antitubercular agents, and contact with adults suffering with drug-resistant TB are important risk factors in development of drug-resistant -TB in children.
Key wordsChildren Drug resistant tuberculosis India Outcome
Unable to display preview. Download preview PDF.
- 1.TB India 2010: RNTCP Status report. Central TB Division, Directorate General of Health Services, Ministry of Health and Family Welfare, Nirman Bhawan, New Delhi — 110001. Available from: http://www.tbcindia.org. Accessed on 24 November, 2010.
- 2.World Health Organization (WHO). Anti-Tuberculosis Drug Resistance in the World. Fourth ‘Global Report. Available at URL: http://www.who.int/tb/publications/2008/drs_report4_26feb08.pdf. Accessed on 31 December, 2011.
- 3.World Health Organization (WHO). Guidelines for the programmatic management of drug-resistant tuberculosis — 2006. Available at URL: http://www.tbrieder.org/publications/books_english/who_treatment_mdr.pdf. Accessed on 31December, 2011.
- 5.World Health Organization (WHO). Guidance on providerinitiated HIV testing and counselling in health facilities. Available at URL: http://www.who.int/hiv/pub/vct/pitc/en/index.html. Accessed on 16February, 2012
- 9.The role of BCG vaccine in the prevention and control of tuberculosis in the United States. A joint statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 1996;45:1–18.Google Scholar
- 10.Sharma SK, Turaga KK, Balamurugan A, Saha PK, Pandey RM, Jain NK, et al. Clinical and genetic risk factors for the development of multi-drug resistant tuberculosis in non-HIV infected patients at a tertiary care center in India: a case-control study. Infect Genet Evol. 2003;3:183–188.PubMedCrossRefGoogle Scholar