To evaluate whether light-emitting diode (LED) phototherapy is as efficacious as compact fluorescent tube (CFT) phototherapy for the treatment of non-hemolytic jaundice in healthy term and late preterm neonates.
Multi-centre open-label randomized controlled trial.
Four tertiary care neonatal units.
Healthy term and late preterm neonates with non-hemolytic jaundice.
Single-surface LED or CFT phototherapy.
Primary outcome variable
Duration of phototherapy.
A total of 272 neonates were randomized to receive LED (n=142) or CFT (n=130) phototherapy. The baseline demographic and biochemical variables were similar in the two groups. The median duration of phototherapy (IQR) in the two groups was comparable (26 (22–36) h vs. 25(22–36) h; P=0.44). At any time point, a similar proportion of neonates were under phototherapy in the two groups (log-rank test, P=0.38). The rate of fall of serum total bilirubin (STB) during phototherapy and the incidence of ‘failure of phototherapy’ were also not different. An equal proportion of neonates had a rebound increase in STB needing restarting of phototherapy. Side effects were rare, comparable in the two groups and included hypothermia, hyperthermia, rash, skin darkening and dehydration.
LED and CFT phototherapy units were equally efficacious in the management of non-hemolytic hyperbilirubinemia in healthy term and late-preterm neonates.
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Kumar, P., Murki, S., Malik, G.K. et al. Light-emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: A multi-center randomized controlled trial . Indian Pediatr 47, 131–137 (2010). https://doi.org/10.1007/s13312-010-0020-7
- Compact fluorescent tube
- Light emitting diode