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Light-emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: A multi-center randomized controlled trial

Abstract

Objective

To evaluate whether light-emitting diode (LED) phototherapy is as efficacious as compact fluorescent tube (CFT) phototherapy for the treatment of non-hemolytic jaundice in healthy term and late preterm neonates.

Study design

Multi-centre open-label randomized controlled trial.

Setting

Four tertiary care neonatal units.

Subjects

Healthy term and late preterm neonates with non-hemolytic jaundice.

Intervention

Single-surface LED or CFT phototherapy.

Primary outcome variable

Duration of phototherapy.

Results

A total of 272 neonates were randomized to receive LED (n=142) or CFT (n=130) phototherapy. The baseline demographic and biochemical variables were similar in the two groups. The median duration of phototherapy (IQR) in the two groups was comparable (26 (22–36) h vs. 25(22–36) h; P=0.44). At any time point, a similar proportion of neonates were under phototherapy in the two groups (log-rank test, P=0.38). The rate of fall of serum total bilirubin (STB) during phototherapy and the incidence of ‘failure of phototherapy’ were also not different. An equal proportion of neonates had a rebound increase in STB needing restarting of phototherapy. Side effects were rare, comparable in the two groups and included hypothermia, hyperthermia, rash, skin darkening and dehydration.

Conclusions

LED and CFT phototherapy units were equally efficacious in the management of non-hemolytic hyperbilirubinemia in healthy term and late-preterm neonates.

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Correspondence to Ashok K. Deorari.

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Kumar, P., Murki, S., Malik, G.K. et al. Light-emitting diodes versus compact fluorescent tubes for phototherapy in neonatal jaundice: A multi-center randomized controlled trial . Indian Pediatr 47, 131–137 (2010). https://doi.org/10.1007/s13312-010-0020-7

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Key Words

  • Compact fluorescent tube
  • Jaundice
  • Light emitting diode
  • Neonate
  • Phototherapy